BTG3

From Wikipedia, the free encyclopedia

BTG family, member 3

Identifiers

BTG3; ANA; MGC8928; TOB5; TOB55; TOFA

External IDs

OMIM: 605674 MGI: 109532 HomoloGene: 4953

Gene ontology
Cellular Component:	• cytoplasm
Biological Process:	• regulation of progression through cell cycle • negative regulation of cell proliferation • negative regulation of progression through mitotic cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006806 (mRNA)
NP_006797 (protein)

XM_622699 (mRNA)
XP_622699 (protein)

Location

Chr 21: 17.89 - 17.91 Mb

n/a

Pubmed search

[1]

[2]

BTG family, member 3, also known as BTG3, is a human gene.^[1]

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system.^[1]

[edit] References

^ ^a ^b Entrez Gene: BTG3 BTG family, member 3.

[edit] Further reading

Matsuda S, Rouault J, Magaud J, Berthet C (2001). "In search of a function for the TIS21/PC3/BTG1/TOB family.". FEBS Lett. 497 (2-3): 67-72. PMID 11377414.
Guéhenneux F, Duret L, Callanan MB, et al. (1997). "Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle.". Leukemia 11 (3): 370-5. PMID 9067576.
Yoshida Y, Matsuda S, Ikematsu N, et al. (1998). "ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system.". Oncogene 16 (20): 2687-93. doi:10.1038/sj.onc.1201805. PMID 9632145.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953.
Birot A, Duret L, Bartholin L, et al. (2000). "Identification and molecular analysis of BANP.". Gene 253 (2): 189-96. PMID 10940556.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.". Jpn. J. Cancer Res. 92 (6): 592-6. PMID 11429045.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Ou YH, Chung PH, Hsu FF, et al. (2007). "The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1.". EMBO J. 26 (17): 3968-80. doi:10.1038/sj.emboj.7601825. PMID 17690688.