BTG2

From Wikipedia, the free encyclopedia

BTG family, member 2

Identifiers

BTG2; PC3; MGC126063; MGC126064; TIS21

External IDs

OMIM: 601597 MGI: 108384 HomoloGene: 31406

Gene ontology
Molecular Function:	• transcription factor activity • protein binding
Biological Process:	• DNA repair • transcription • regulation of transcription, DNA-dependent • protein amino acid methylation • negative regulation of cell proliferation • anterior/posterior pattern formation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006763 (mRNA)
NP_006754 (protein)

NM_007570 (mRNA)
NP_031596 (protein)

Location

Chr 1: 201.54 - 201.55 Mb

Chr 1: 135.89 - 135.9 Mb

Pubmed search

[1]

[2]

BTG family, member 2, also known as BTG2, is a human gene.^[1]

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle.^[1]

[edit] References

^ ^a ^b Entrez Gene: BTG2 BTG family, member 2.

[edit] Further reading

Puisieux A, Magaud JP (1999). "[Mechanisms of BTG2 activity, a transcriptional target of p53: evidences and hypothesis.]". Bulletin du cancer 86 (4): 358–64. PMID 10341341.
Tirone F (2001). "The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?". J. Cell. Physiol. 187 (2): 155–65. doi:10.1002/jcp.1062. PMID 11267995.
Matsuda S, Rouault J, Magaud J, Berthet C (2001). "In search of a function for the TIS21/PC3/BTG1/TOB family.". FEBS Lett. 497 (2-3): 67–72. PMID 11377414.
Fletcher BS, Lim RW, Varnum BC, et al. (1991). "Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters.". J. Biol. Chem. 266 (22): 14511–8. PMID 1713584.
Lin WJ, Gary JD, Yang MC, et al. (1996). "The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase.". J. Biol. Chem. 271 (25): 15034–44. PMID 8663146.
Montagnoli A, Guardavaccaro D, Starace G, Tirone F (1997). "Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition.". Cell Growth Differ. 7 (10): 1327–36. PMID 8891336.
Rouault JP, Falette N, Guéhenneux F, et al. (1997). "Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway.". Nat. Genet. 14 (4): 482–6. doi:10.1038/ng1296-482. PMID 8944033.
Rouault JP, Prévôt D, Berthet C, et al. (1998). "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex.". J. Biol. Chem. 273 (35): 22563–9. PMID 9712883.
Walden PD, Lefkowitz GK, Ficazzola M, et al. (1999). "Identification of genes associated with stromal hyperplasia and glandular atrophy of the prostate by mRNA differential display.". Exp. Cell Res. 245 (1): 19–26. doi:10.1006/excr.1998.4237. PMID 9828097.
Iacopetti P, Michelini M, Stuckmann I, et al. (1999). "Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division.". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4639–44. PMID 10200315.
Prévôt D, Voeltzel T, Birot AM, et al. (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation.". J. Biol. Chem. 275 (1): 147–53. PMID 10617598.
Guardavaccaro D, Corrente G, Covone F, et al. (2000). "Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription.". Mol. Cell. Biol. 20 (5): 1797–815. PMID 10669755.
Prévôt D, Morel AP, Voeltzel T, et al. (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
Lin WJ, Chang YF, Wang WL, Huang CY (2001). "Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1.". Biochem. J. 354 (Pt 3): 635–43. PMID 11237868.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.". Jpn. J. Cancer Res. 92 (6): 592–6. PMID 11429045.
Ficazzola MA, Fraiman M, Gitlin J, et al. (2001). "Antiproliferative B cell translocation gene 2 protein is down-regulated post-transcriptionally as an early event in prostate carcinogenesis.". Carcinogenesis 22 (8): 1271–9. PMID 11470758.
Duriez C, Falette N, Audoynaud C, et al. (2002). "The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene.". Gene 282 (1-2): 207–14. PMID 11814693.