BTG1

From Wikipedia, the free encyclopedia

B-cell translocation gene 1, anti-proliferative

Identifiers

External IDs

OMIM: 109580 MGI: 88215 HomoloGene: 37521

Gene ontology
Molecular Function:	• transcription cofactor activity • kinase binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• protein amino acid methylation • spermatid development • negative regulation of cell proliferation • cell migration • negative regulation of cell growth • regulation of apoptosis • positive regulation of enzyme activity • regulation of transcription • positive regulation of endothelial cell differentiation • positive regulation of myoblast differentiation • positive regulation of angiogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001731 (mRNA)
NP_001722 (protein)

NM_007569 (mRNA)
NP_031595 (protein)

Location

Chr 12: 91.06 - 91.06 Mb

n/a

Pubmed search

[1]

[2]

B-cell translocation gene 1, anti-proliferative, also known as BTG1, is a human gene.^[1]

The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. It negatively regulates cell proliferation.^[1]

[edit] References

^ ^a ^b Entrez Gene: BTG1 B-cell translocation gene 1, anti-proliferative.

[edit] Further reading

Rouault JP, Rimokh R, Tessa C, et al. (1992). "BTG1, a member of a new family of antiproliferative genes.". EMBO J. 11 (4): 1663-70. PMID 1373383.
Rimokh R, Rouault JP, Wahbi K, et al. (1991). "A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia.". Genes Chromosomes Cancer 3 (1): 24-36. PMID 2069907.
Lin WJ, Gary JD, Yang MC, et al. (1996). "The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase.". J. Biol. Chem. 271 (25): 15034-44. PMID 8663146.
Corjay MH, Kearney MA, Munzer DA, et al. (1998). "Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human.". Lab. Invest. 78 (7): 847-58. PMID 9690562.
Bogdan JA, Adams-Burton C, Pedicord DL, et al. (1999). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.". Biochem. J. 336 ( Pt 2): 471-81. PMID 9820826.
Prévôt D, Voeltzel T, Birot AM, et al. (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation.". J. Biol. Chem. 275 (1): 147-53. PMID 10617598.
Prévôt D, Morel AP, Voeltzel T, et al. (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.". J. Biol. Chem. 276 (13): 9640-8. doi:10.1074/jbc.M008201200. PMID 11136725.
Rodier A, Rochard P, Berthet C, et al. (2001). "Identification of functional domains involved in BTG1 cell localization.". Oncogene 20 (21): 2691-703. doi:10.1038/sj.onc.1204398. PMID 11420681.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.". Jpn. J. Cancer Res. 92 (6): 592-6. PMID 11429045.
Berthet C, Guéhenneux F, Revol V, et al. (2002). "Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects.". Genes Cells 7 (1): 29-39. PMID 11856371.
Sasajima H, Nakagawa K, Yokosawa H (2002). "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.". Eur. J. Biochem. 269 (14): 3596-604. PMID 12135500.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bakker WJ, Blázquez-Domingo M, Kolbus A, et al. (2004). "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.". J. Cell Biol. 164 (2): 175-84. doi:10.1083/jcb.200307056. PMID 14734530.
Iwai K, Hirata K, Ishida T, et al. (2004). "An anti-proliferative gene BTG1 regulates angiogenesis in vitro.". Biochem. Biophys. Res. Commun. 316 (3): 628-35. doi:10.1016/j.bbrc.2004.02.095. PMID 15033446.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Busson M, Carazo A, Seyer P, et al. (2005). "Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation.". Oncogene 24 (10): 1698-710. doi:10.1038/sj.onc.1208373. PMID 15674337.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.