BTF3

From Wikipedia, the free encyclopedia

Basic transcription factor 3

Identifiers

BTF3; BETA-NAC; BTF3a; BTF3b; NACB

External IDs

OMIM: 602542 MGI: 1202875 HomoloGene: 37453

Gene ontology
Molecular Function:	• RNA polymerase II transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001037637 (mRNA)
NP_001032726 (protein)

NM_145455 (mRNA)
NP_663430 (protein)

Location

n/a

Chr 13: 99.41 - 99.42 Mb

Pubmed search

[1]

[2]

Basic transcription factor 3, also known as BTF3, is a human gene.^[1]

This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.^[1]

[edit] References

^ ^a ^b Entrez Gene: BTF3 basic transcription factor 3.

[edit] Further reading

Kanno M, Chalut C, Egly JM (1992). "Genomic structure of the putative BTF3 transcription factor.". Gene 117 (2): 219-28. PMID 1386332.
Zheng XM, Black D, Chambon P, Egly JM (1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3.". Nature 344 (6266): 556-9. doi:10.1038/344556a0. PMID 2320128.
Wiedmann B, Sakai H, Davis TA, Wiedmann M (1994). "A protein complex required for signal-sequence-specific sorting and translocation.". Nature 370 (6489): 434-40. doi:10.1038/370434a0. PMID 8047162.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Grein S, Pyerin W (1999). "BTF3 is a potential new substrate of protein kinase CK2.". Mol. Cell. Biochem. 191 (1-2): 121-8. PMID 10094400.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440-5. doi:10.1038/88107. PMID 11329013.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Freire MA (2005). "Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex.". Gene 345 (2): 271-7. doi:10.1016/j.gene.2004.11.030. PMID 15716105.
Kusumawidjaja G, Kayed H, Giese N, et al. (2007). "Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells.". Cancer Biol. Ther. 6 (3): 367-76. PMID 17312387.