BTAF1

From Wikipedia, the free encyclopedia

BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)

Identifiers

BTAF1; KIAA0940; MGC138406; MOT1; TAF(II)170; TAF172; TAFII170

External IDs

OMIM: 605191 MGI: 2147538 HomoloGene: 31978

Gene ontology
Molecular Function:	• nucleotide binding • transcription factor activity • helicase activity • ATP binding • hydrolase activity
Cellular Component:	• nucleus
Biological Process:	• negative regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003972 (mRNA)
NP_003963 (protein)

XM_001001026 (mRNA)
XP_001001026 (protein)

Location

Chr 10: 93.67 - 93.78 Mb

Chr 19: 37.05 - 37.08 Mb

Pubmed search

[1]

[2]

BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae), also known as BTAF1, is a human gene.^[1]

Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae).

[edit] Further reading

Zhou Q, Sharp PA (1995). "Novel mechanism and factor for regulation by HIV-1 Tat.". EMBO J. 14 (2): 321–8. PMID 7835343.
Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro.". J. Biol. Chem. 270 (5): 2274–83. PMID 7836461.
Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.". J. Virol. 68 (11): 7188–99. PMID 7933101.
Kashanchi F, Piras G, Radonovich MF, et al. (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat.". Nature 367 (6460): 295–9. doi:10.1038/367295a0. PMID 8121496.
Wang Z, Morris GF, Rice AP, et al. (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (2): 128–38. PMID 8680883.
Pendergrast PS, Morrison D, Tansey WP, Hernandez N (1996). "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly.". J. Virol. 70 (8): 5025–34. PMID 8764009.
Kashanchi F, Khleif SN, Duvall JF, et al. (1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex.". J. Virol. 70 (8): 5503–10. PMID 8764062.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605–10. PMID 8849451.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.". J. Biol. Chem. 272 (11): 6951–8. PMID 9054383.
Scully R, Anderson SF, Chao DM, et al. (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. PMID 9159119.
van der Knaap JA, Borst JW, van der Vliet PC, et al. (1997). "Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila.". Proc. Natl. Acad. Sci. U.S.A. 94 (22): 11827–32. PMID 9342322.
Chicca JJ, Auble DT, Pugh BF (1998). "Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1.". Mol. Cell. Biol. 18 (3): 1701–10. PMID 9488487.
Van Der Knaap JA, Van Den Boom V, Kuipers J, et al. (2000). "The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization.". Biochem. J. 345 Pt 3: 521–7. PMID 10642510.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wadhwa R, Yaguchi T, Hasan MK, et al. (2003). "Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation.". Biochem. Biophys. Res. Commun. 302 (4): 735–42. PMID 12646231.
Pereira LA, Klejman MP, Ruhlmann C, et al. (2004). "Molecular architecture of the basal transcription factor B-TFIID.". J. Biol. Chem. 279 (21): 21802–7. doi:10.1074/jbc.M313519200. PMID 14988402.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Klejman MP, Pereira LA, van Zeeburg HJ, et al. (2004). "NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein.". Mol. Cell. Biol. 24 (22): 10072–82. doi:10.1128/MCB.24.22.10072-10082.2004. PMID 15509807.
Grob P, Cruse MJ, Inouye C, et al. (2006). "Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues.". Structure 14 (3): 511–20. doi:10.1016/j.str.2005.11.020. PMID 16531235.