BRWD2

From Wikipedia, the free encyclopedia


Bromodomain and WD repeat domain containing 2
Identifiers
Symbol(s) BRWD2; WDR11; DKFZp434L1715; DR11; FLJ42531; WDR15
External IDs OMIM: 606417 MGI: 1920230 HomoloGene: 41229
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55717 207425
Ensembl ENSG00000120008 ENSMUSG00000042055
Uniprot Q9BZH6 n/a
Refseq NM_018117 (mRNA)
NP_060587 (protein)		 NM_172255 (mRNA)
NP_758459 (protein)
Location Chr 10: 122.6 - 122.66 Mb Chr 7: 129.38 - 129.43 Mb
Pubmed search [1] [2]

Bromodomain and WD repeat domain containing 2, also known as BRWD2, is a human gene.[1]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.[1]

[edit] References

  1. ^ a b Entrez Gene: BRWD2 bromodomain and WD repeat domain containing 2.

[edit] Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Katoh M, Katoh M (2003). "Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26.". Int. J. Mol. Med. 11 (5): 579-83. PMID 12684693. 
  • Katoh M, Katoh M (2003). "FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26.". Int. J. Oncol. 22 (5): 1155-9. PMID 12684685. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Chernova OB, Hunyadi A, Malaj E, et al. (2001). "A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells.". Oncogene 20 (38): 5378-92. doi:10.1038/sj.onc.1204694. PMID 11536051. 
  • Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65-73. PMID 10718198. 
 This article on a gene on chromosome 10 is a stub. You can help Wikipedia by expanding it.