BRWD1

From Wikipedia, the free encyclopedia

Bromodomain and WD repeat domain containing 1

Identifiers

BRWD1; C21orf107; FLJ43918; N143; WDR9

External IDs

Gene ontology
Molecular Function:	• protein binding • transcription regulator activity
Cellular Component:	• cellular_component • nucleus
Biological Process:	• transcription • regulation of transcription from RNA polymerase II promoter • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001007246 (mRNA)
NP_001007247 (protein)

NM_145125 (mRNA)
NP_660107 (protein)

Location

Chr 21: 39.48 - 39.61 Mb

Chr 16: 96.1 - 96.19 Mb

Pubmed search

[1]

[2]

Bromodomain and WD repeat domain containing 1, also known as BRWD1, is a human gene.^[1]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats, and the function of this protein is not known. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates 3 transcript variants diverging at the 3' ends.^[1]

[edit] References

^ ^a ^b Entrez Gene: BRWD1 bromodomain and WD repeat domain containing 1.

[edit] Further reading

Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.". BMC Genomics 7: 155. doi:10.1186/1471-2164-7-155. PMID 16780588.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Huang H, Rambaldi I, Daniels E, Featherstone M (2004). "Expression of the Wdr9 gene and protein products during mouse development.". Dev. Dyn. 227 (4): 608-14. doi:10.1002/dvdy.10344. PMID 12889071.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ramos VC, Vidal-Taboada J, Bergoñon S, et al. (2002). "Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21.". Biochim. Biophys. Acta 1577 (3): 377-83. PMID 12359327.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953.
Vidal-Taboada JM, Bergoñón S, Sánchez M, et al. (1998). "High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2.". Biochem. Biophys. Res. Commun. 243 (2): 572-8. doi:10.1006/bbrc.1998.8141. PMID 9480850.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.