BRUNOL4

From Wikipedia, the free encyclopedia

Bruno-like 4, RNA binding protein (Drosophila)

PDB rendering based on 2dgp.

Available structures: 2dgp, 2dnk

Identifiers

Symbol(s)

BRUNOL4; BRUNOL-4; CELF4

External IDs

MGI: 1932407 HomoloGene: 23202

Gene ontology
Molecular Function:	• nucleotide binding • translation repressor activity, nucleic acid binding • nucleic acid binding • BRE binding
Cellular Component:	• nucleus • ribonucleoprotein complex
Biological Process:	• germ cell development • embryonic development • RNA interference

Orthologs

Human

Mouse

Refseq

XM_001128998 (mRNA)
XP_001128998 (protein)

XM_986215 (mRNA)
XP_991309 (protein)

Location

Chr 18: 33.08 - 33.4 Mb

Chr 18: 25.62 - 25.9 Mb

Pubmed search

[1]

[2]

Bruno-like 4, RNA binding protein (Drosophila), also known as BRUNOL4, is a human gene.^[1]

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Several transcript variants encoding different isoforms have been found for this gene, but their full-length nature has not been determined yet.^[1]

[edit] References

^ ^a ^b Entrez Gene: BRUNOL4 bruno-like 4, RNA binding protein (Drosophila).

[edit] Further reading

Szafranski K, Schindler S, Taudien S, et al. (2008). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918.
Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo.". Nucleic Acids Res. 33 (9): 2769-80. doi:10.1093/nar/gki561. PMID 15894795.
Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo.". Nucleic Acids Res. 32 (3): 1232-41. doi:10.1093/nar/gkh275. PMID 14973222.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.". Mol. Med. 8 (1): 56-64. PMID 11984006.
Ladd AN, Charlet N, Cooper TA (2001). "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.". Mol. Cell. Biol. 21 (4): 1285-96. doi:10.1128/MCB.21.4.1285-1296.2001. PMID 11158314.
Good PJ, Chen Q, Warner SJ, Herring DC (2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.". J. Biol. Chem. 275 (37): 28583-92. doi:10.1074/jbc.M003083200. PMID 10893231.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.