Bromoxynil nitrilase

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In enzymology, a bromoxynil nitrilase (EC 3.5.5.6) is an enzyme that catalyzes the chemical reaction

3,5-dibromo-4-hydroxybenzonitrile + 2 H₂O 3,5-dibromo-4-hydroxy-benzoate + NH₃

Thus, the two substrates of this enzyme are 3,5-dibromo-4-hydroxybenzonitrile and H₂O, whereas its two products are 3,5-dibromo-4-hydroxy-benzoate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is 3,5-dibromo-4-hydroxybenzonitrile aminohydrolase. This enzyme participates in 1,4-dichlorobenzene degradation.

[edit] References

• IUBMB entry for 3.5.5.6
• BRENDA references for 3.5.5.6 (Recommended.)
• PubMed references for 3.5.5.6
• PubMed Central references for 3.5.5.6
• Google Scholar references for 3.5.5.6
• Stalker DM, Malyj LD, McBride KE (1988). "Purification and properties of a nitrilase specific for the herbicide bromoxynil and corresponding nucleotide sequence analysis of the bxn gene". J. Biol. Chem. 263: 6310–4. PMID 2834373. 

[edit] External links

The CAS registry number for this enzyme class is 157857-12-0.

• IUBMB entry for 3.5.5.6

• KEGG entry for 3.5.5.6

• BRENDA entry for 3.5.5.6

• NiceZyme view of 3.5.5.6

• EC2PDB: PDB structures for 3.5.5.6

• PRIAM entry for 3.5.5.6

• PUMA2 entry for 3.5.5.6

• IntEnz: Integrated Enzyme entry for 3.5.5.6

• MetaCyc entry for 3.5.5.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018761: bromoxynil nitrilase

• AMIGO entry for GO code 0018761: bromoxynil nitrilase