Brodimoprim

From Wikipedia, the free encyclopedia

Brodimoprim
Systematic (IUPAC) name
5-[(4-bromo-3,5-dimethoxyphenyl)methyl]
pyrimidine-2,4-diamine
Identifiers
CAS number  ?
ATC code J01EA02
PubChem 68760
Chemical data
Formula C13H15BrN4O2 
Mol. mass 339.188 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Brodimoprim is a structural derivative of trimethoprim. In brodimoprim, the 4-methoxy group of trimethoprim is replaced with a bromine atom.

As trimethoprim, brodimoprim is a selective inhibitor of bacterial dihydrofolate reductase.[1]

[edit] References

  1. ^ Thomson CJ (1993). "Trimethoprim and brodimoprim resistance of gram-positive and gram-negative bacteria". J Chemother 5 (6): 45864. PMID 8195838.