BRMS1

From Wikipedia, the free encyclopedia


Breast cancer metastasis suppressor 1
Identifiers
Symbol(s) BRMS1; DKFZp564A063
External IDs OMIM: 606259 MGI: 2388804 HomoloGene: 32260
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 25855 107392
Ensembl ENSG00000174744 ENSMUSG00000024888
Uniprot Q9HCU9 Q547N0
Refseq NM_001024957 (mRNA)
NP_001020128 (protein)		 NM_134155 (mRNA)
NP_598916 (protein)
Location Chr 11: 65.86 - 65.87 Mb Chr 19: 5.05 - 5.05 Mb
Pubmed search [1] [2]

Breast cancer metastasis suppressor 1, also known as BRMS1, is a human gene.[1]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[2] The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: BRMS1 breast cancer metastasis suppressor 1.
  2. ^ Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

[edit] Further reading

  • Meehan WJ, Welch DR (2003). "Breast cancer metastasis suppressor 1: update.". Clin. Exp. Metastasis 20 (1): 45–50. PMID 12650606. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Seraj MJ, Samant RS, Verderame MF, Welch DR (2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13.". Cancer Res. 60 (11): 2764–9. PMID 10850410. 
  • Samant RS, Debies MT, Shevde LA, et al. (2002). "Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1).". Int. J. Cancer 97 (1): 15–20. PMID 11774238. 
  • Shevde LA, Samant RS, Goldberg SF, et al. (2002). "Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1.". Exp. Cell Res. 273 (2): 229–39. doi:10.1006/excr.2001.5452. PMID 11822878. 
  • Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. (2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.". J. Clin. Endocrinol. Metab. 87 (11): 5336–9. PMID 12414911. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Meehan WJ, Samant RS, Hopper JE, et al. (2004). "Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.". J. Biol. Chem. 279 (2): 1562–9. doi:10.1074/jbc.M307969200. PMID 14581478. 
  • Cicek M, Samant RS, Kinter M, et al. (2004). "Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells.". Clin. Exp. Metastasis 21 (2): 149–57. PMID 15168732. 
  • Nikolaev AY, Papanikolaou NA, Li M, et al. (2004). "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex.". Biochem. Biophys. Res. Commun. 323 (4): 1216–22. doi:10.1016/j.bbrc.2004.08.227. PMID 15451426. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Stark AM, Tongers K, Maass N, et al. (2005). "Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases.". J. Cancer Res. Clin. Oncol. 131 (3): 191–8. doi:10.1007/s00432-004-0629-9. PMID 15592684. 
  • DeWald DB, Torabinejad J, Samant RS, et al. (2005). "Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells.". Cancer Res. 65 (3): 713–7. PMID 15705865. 
  • Cicek M, Fukuyama R, Welch DR, et al. (2005). "Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity.". Cancer Res. 65 (9): 3586–95. doi:10.1158/0008-5472.CAN-04-3139. PMID 15867352. 
  • Hurst DR, Mehta A, Moore BP, et al. (2006). "Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.". Biochem. Biophys. Res. Commun. 348 (4): 1429–35. doi:10.1016/j.bbrc.2006.08.005. PMID 16919237. 
  • Samant RS, Clark DW, Fillmore RA, et al. (2007). "Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation.". Mol. Cancer 6: 6. doi:10.1186/1476-4598-6-6. PMID 17227585. 
  • Rivera J, Megias D, Bravo J (2007). "Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1.". J. Proteome Res. 6 (10): 4006–18. doi:10.1021/pr0703167. PMID 17854218. 
 This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it.