BRF2 (gene)

From Wikipedia, the free encyclopedia

BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like

Identifiers

BRF2; BRFU; FLJ11052; TFIIIB50

External IDs

OMIM: 607013 MGI: 1913903 HomoloGene: 10127

Gene ontology
Molecular Function:	• zinc ion binding • transcription regulator activity
Cellular Component:	• transcription factor complex
Biological Process:	• transcription initiation • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018310 (mRNA)
NP_060780 (protein)

NM_025686 (mRNA)
NP_079962 (protein)

Location

Chr 8: 37.82 - 37.83 Mb

Chr 8: 28.59 - 28.59 Mb

Pubmed search

[1]

[2]

BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like, also known as BRF2, is a human gene.^[1]

This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: BRF2 BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like.

[edit] Further reading

Sutcliffe JE, Cairns CA, McLees A, et al. (1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130.". Mol. Cell. Biol. 19 (6): 4255-61. PMID 10330166.
Schramm L, Pendergrast PS, Sun Y, Hernandez N (2000). "Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters.". Genes Dev. 14 (20): 2650-63. PMID 11040218.
Teichmann M, Wang Z, Roeder RG (2001). "A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements.". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14200-5. doi:10.1073/pnas.97.26.14200. PMID 11121026.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.". Genome Res. 11 (8): 1392-403. doi:10.1101/gr.175501. PMID 11483580.
Cabart P, Murphy S (2001). "BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein.". J. Biol. Chem. 276 (46): 43056-64. doi:10.1074/jbc.M108515200. PMID 11564744.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hinkley CS, Hirsch HA, Gu L, et al. (2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.". J. Biol. Chem. 278 (20): 18649-57. doi:10.1074/jbc.M204247200. PMID 12621023.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Saxena A, Ma B, Schramm L, Hernandez N (2005). "Structure-function analysis of the human TFIIB-related factor II protein reveals an essential role for the C-terminal domain in RNA polymerase III transcription.". Mol. Cell. Biol. 25 (21): 9406-18. doi:10.1128/MCB.25.21.9406-9418.2005. PMID 16227591.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.