BRE (gene)

From Wikipedia, the free encyclopedia

Brain and reproductive organ-expressed (TNFRSF1A modulator)

Identifiers

BRE; BRCC4; BRCC45

External IDs

OMIM: 610497 MGI: 1333875 HomoloGene: 3604

Gene ontology
Molecular Function:	• peroxisome targeting sequence binding • tumor necrosis factor receptor binding • protein binding
Cellular Component:	• nuclear ubiquitin ligase complex • nucleus • cytoplasm
Biological Process:	• ubiquitin cycle • apoptosis • response to DNA damage stimulus • signal transduction • positive regulation of anti-apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004899 (mRNA)
NP_004890 (protein)

NM_144541 (mRNA)
NP_653124 (protein)

Location

Chr 2: 27.97 - 28.42 Mb

Chr 5: 31.97 - 32.36 Mb

Pubmed search

[1]

[2]

Brain and reproductive organ-expressed (TNFRSF1A modulator), also known as BRE, is a human gene.^[1]

[edit] References

^ Entrez Gene: BRE brain and reproductive organ-expressed (TNFRSF1A modulator).

[edit] Further reading

Li L, Yoo H, Becker FF, et al. (1995). "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid.". Biochem. Biophys. Res. Commun. 206 (2): 764-74. PMID 7826398.
Gu C, Castellino A, Chan JY, Chao MV (1998). "BRE: a modulator of TNF-alpha action.". FASEB J. 12 (12): 1101-8. PMID 9737713.
Miao J, Panesar NS, Chan KT, et al. (2001). "Differential expression of a stress-modulating gene, BRE, in the adrenal gland, in adrenal neoplasia, and in abnormal adrenal tissues.". J. Histochem. Cytochem. 49 (4): 491-500. PMID 11259452.
Ching AK, Li PS, Li Q, et al. (2001). "Expression of human BRE in multiple isoforms.". Biochem. Biophys. Res. Commun. 288 (3): 535-45. doi:10.1006/bbrc.2001.5801. PMID 11676476.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dong Y, Hakimi MA, Chen X, et al. (2004). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.". Mol. Cell 12 (5): 1087-99. PMID 14636569.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Li Q, Ching AK, Chan BC, et al. (2005). "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway.". J. Biol. Chem. 279 (50): 52106-16. doi:10.1074/jbc.M408678200. PMID 15465831.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Chan BC, Li Q, Chow SK, et al. (2005). "BRE enhances in vivo growth of tumor cells.". Biochem. Biophys. Res. Commun. 326 (2): 268-73. doi:10.1016/j.bbrc.2004.11.013. PMID 15582573.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.