BRDT

From Wikipedia, the free encyclopedia

Bromodomain, testis-specific

Identifiers

BRDT; BRD6

External IDs

OMIM: 602144 MGI: 1891374 HomoloGene: 21064

Gene ontology
Molecular Function:	• transcription coactivator activity • protein serine/threonine kinase activity • histone binding
Cellular Component:	• nucleus
Biological Process:	• chromatin remodeling • transcription • regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001726 (mRNA)
NP_001717 (protein)

NM_001079873 (mRNA)
NP_001073342 (protein)

Location

n/a

Chr 5: 107.57 - 107.63 Mb

Pubmed search

[1]

[2]

Bromodomain, testis-specific, also known as BRDT, is a human gene.^[1]

BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Two transcript variants encoding the same protein have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: BRDT bromodomain, testis-specific.

[edit] Further reading

Zheng Y, Yuan W, Zhou Z, et al. (2005). "Molecular cloning and expression of a novel alternative splice variant of BRDT gene.". Int. J. Mol. Med. 15 (2): 315-21. PMID 15647849.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Pivot-Pajot C, Caron C, Govin J, et al. (2003). "Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein.". Mol. Cell. Biol. 23 (15): 5354-65. PMID 12861021.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Scanlan MJ, Altorki NK, Gure AO, et al. (2000). "Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9.". Cancer Lett. 150 (2): 155-64. PMID 10704737.
Dhalluin C, Carlson JE, Zeng L, et al. (1999). "Structure and ligand of a histone acetyltransferase bromodomain.". Nature 399 (6735): 491-6. doi:10.1038/20974. PMID 10365964.
Jones MH, Numata M, Shimane M (1998). "Identification and characterization of BRDT: A testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh.". Genomics 45 (3): 529-34. doi:10.1006/geno.1997.5000. PMID 9367677.