BRD7

From Wikipedia, the free encyclopedia

Bromodomain containing 7

Identifiers

BRD7; BP75; CELTIX1; NAG4

External IDs

Gene ontology
Molecular Function:	• transcription factor binding • histone binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• regulation of transcription from RNA polymerase II promoter • Wnt receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013263 (mRNA)
NP_037395 (protein)

NM_012047 (mRNA)
NP_036177 (protein)

Location

Chr 16: 48.91 - 48.96 Mb

Chr 8: 91.22 - 91.25 Mb

Pubmed search

[1]

[2]

Bromodomain containing 7, also known as BRD7, is a human gene.^[1]

[edit] References

^ Entrez Gene: BRD7 bromodomain containing 7.

[edit] Further reading

Cuppen E, van Ham M, Pepers B, et al. (1999). "Identification and molecular characterization of BP75, a novel bromodomain-containing protein.". FEBS Lett. 459 (3): 291–8. PMID 10526152.
Staal A, Enserink JM, Stein JL, et al. (2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2.". J. Cell. Physiol. 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kzhyshkowska J, Rusch A, Wolf H, Dobner T (2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7.". Biochem. J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. PMID 12489984.
Zhou M, Peng C, Nie XM, et al. (2003). "[Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues]". Ai Zheng 22 (2): 123–7. PMID 12600283.
Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–96. PMID 12766061.
Zhang XM, Wang XY, Sheng SR, et al. (2003). "Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer.". World J. Gastroenterol. 9 (8): 1729–33. PMID 12918109.
Kim S, Lee J, Park J, Chung J (2003). "BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta.". Cancer Res. 63 (16): 4792–5. PMID 12941796.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhou J, Ma J, Zhang BC, et al. (2004). "BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways.". J. Cell. Physiol. 200 (1): 89–98. doi:10.1002/jcp.20013. PMID 15137061.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Peng C, Zhou J, Liu HY, et al. (2006). "The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain.". J. Cell. Biochem. 97 (4): 882–92. doi:10.1002/jcb.20645. PMID 16265664.
Zhou M, Liu H, Xu X, et al. (2006). "Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression.". J. Cell. Biochem. 98 (4): 920–30. doi:10.1002/jcb.20788. PMID 16475162.
Zhou M, Xu XJ, Zhou HD, et al. (2007). "BRD2 is one of BRD7-interacting proteins and its over-expression could initiate apoptosis.". Mol. Cell. Biochem. 292 (1-2): 205–12. doi:10.1007/s11010-006-9233-4. PMID 16786191.
Liu H, Peng C, Zhou M, et al. (2006). "Cloning and characterization of the BRD7 gene promoter.". DNA Cell Biol. 25 (6): 346–58. doi:10.1089/dna.2006.25.346. PMID 16792505.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.