Branched-chain-2-oxoacid decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a branched-chain-2-oxoacid decarboxylase (EC 4.1.1.72) is an enzyme that catalyzes the chemical reaction

(3S)-3-methyl-2-oxopentanoate 2-methylbutanal + CO₂

Hence, this enzyme has one substrate, (3S)-3-methyl-2-oxopentanoate, and two products, 2-methylbutanal and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming). Other names in common use include branched-chain oxo acid decarboxylase, branched-chain alpha-keto acid decarboxylase, branched-chain keto acid decarboxylase, BCKA, and (3S)-3-methyl-2-oxopentanoate carboxy-lyase.

[edit] References

• IUBMB entry for 4.1.1.72
• BRENDA references for 4.1.1.72 (Recommended.)
• PubMed references for 4.1.1.72
• PubMed Central references for 4.1.1.72
• Google Scholar references for 4.1.1.72
• Oku H, Kaneda T (1988). "Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase". J. Biol. Chem. 263: 18386–96. PMID 3142877. 

[edit] External links

The CAS registry number for this enzyme class is 63653-19-0.

• IUBMB entry for 4.1.1.72

• KEGG entry for 4.1.1.72

• BRENDA entry for 4.1.1.72

• NiceZyme view of 4.1.1.72

• EC2PDB: PDB structures for 4.1.1.72

• PRIAM entry for 4.1.1.72

• PUMA2 entry for 4.1.1.72

• IntEnz: Integrated Enzyme entry for 4.1.1.72

• MetaCyc entry for 4.1.1.72

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047433: branched-chain-2-oxoacid decarboxylase

• AMIGO entry for GO code 0047433: branched-chain-2-oxoacid decarboxylase