Brain zaps

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Brain zaps, also known as "brain shocks," "brain shivers" or "head shocks", are a fairly common withdrawal symptom experienced during discontinuation (or reduction of dose) of SSRI and SNRI antidepressant drugs.^{[citation needed]} The symptom is described as brief but repeated electric shock-like sensations in the brain and head. The effect is not only confined to withdrawal periods for all sufferers, but also are experienced while actually taking the prescribed medication (although less commonly), and have been known to continue for years after withdrawal from the associated medication.

The phenomenon is most commonly associated with paroxetine (Paxil, Seroxat), fluoxetine (Prozac), venlafaxine (Effexor), sertraline (Zoloft), duloxetine (Cymbalta), fluvoxamine (Luvox), citalopram (Celexa), escitalopram (Lexapro), and tramadol (Ultram).

As of 1997, a sizable minority of medical professionals were poorly aware of the existence of antidepressant withdrawal symptoms.^[1] Subsequent review in 2005 of adverse event reporting showed that descriptions of "electric shocks" from patients on paroxetine had been reported more frequently than some other symptoms,^[2] but had wrongly coded and that "patients provided reports that were much richer in their descriptions of behavioural phenomena and feelings than the YC reports".^[3]

In more recent years, drug companies have added to their list of potential side-effects of many of these medications the possibility of "sensory disturbances", believed to be in reference to the strengthening body of anecdotal evidence about this phenomenon's existence.^{[citation needed]}

1 Description
2 Mechanism of Action
3 See also
4 References
5 External links

[edit] Description

"Brain zaps" are said to defy description for whoever has not experienced them, but the most common themes are of a sudden "jolt," likened to an electric shock, apparently occurring or originating within the brain itself, with associated disorientation for a few seconds. The phenomenon is most often reported as a brief, wave-like electrical pulse that quickly travels across the surface of (or through) the brain. Some people experience these "waves" through the rest of their body, but the sensation dissipates quickly. They are sometimes accompanied by brief tinnitus and vertigo-like feelings. Immediately following this shock is a light-headedness that may last for up to ten seconds. The sensation has also been described by many as a flashbulb going off inside the head or brain. Moving one's eyes from side to side quickly while open has also been known to trigger these zaps and sometimes causing them to come in rapid succession. It is thought to be a form of neuro-epileptiform activity. It is also possible that these brain zaps occur when the brain is at its maximum speed of thought, and the brain zaps act as a way to stop the brain from overloading itself due to the side effects of antidepressants.^[4]^[5]^[6]

As withdrawal time increases, the frequency of the shocks decreases. At their peak, brain zaps have been associated with severe headaches. They may last for a period of several weeks after the last dose and usually resolve completely within a month or two. However, anecdotal reports of "zaps" during a protracted withdrawal are known to last a year or longer (confirmation of this is required).

[edit] Mechanism of Action

Paresthesia and "electric shock sensations" are clinical terms used to describe this symptom,^{[citation needed]} though paresthesia by definition is clinically incorrect.

The "brain zap" effect appears to be nearly unique to serotonergic drug formulations which have an extremely short elimination half-life; that is, they are more quickly metabolized by the liver and leave the general circulation faster than longer half-life antidepressants such as fluoxetine (Prozac). This attribute of abruptness leaves the brain a relatively short time to adapt to a major neurochemical change when the medication is stopped, and the symptoms may be caused by the brain's attempt at readjustment. There is no current evidence that these "zaps" present any danger to the patient experiencing them and have rarely been reported as painful however they can be very disconcerting to those patients who have no prior warning or knowledge of them.

Tranylcypromine (Parnate) used at high doses has also been known for causing brain zaps, which may, in some cases, start at the base of the spine and progress to the head, or may occur exclusively in the head.

Brain zaps have also been commonly reported following periods of heavy use of the drug MDMA (Ecstasy).^{[citation needed]}