BRAF (gene)

From Wikipedia, the free encyclopedia

V-raf murine sarcoma viral oncogene homolog B1

PDB rendering based on 1uwh.

Available structures: 1uwh, 1uwj, 2fb8

Identifiers

Symbol(s)

BRAF; B-raf 1; BRAF1; MGC126806; MGC138284; RAFB1

External IDs

OMIM: 164757 HomoloGene: 3197

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • receptor signaling protein activity • ATP binding • zinc ion binding • transferase activity • diacylglycerol binding • metal ion binding
Cellular Component:	• cytoplasm • plasma membrane
Biological Process:	• protein amino acid phosphorylation • anti-apoptosis • intracellular signaling cascade • organ morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_004333 (mRNA)
NP_004324 (protein)

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n/a (protein)

Location

Chr 7: 140.08 - 140.27 Mb

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Pubmed search

[1]

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V-raf murine sarcoma viral oncogene homolog B1, also known as BRAF, is a human gene.

The BRAF gene makes a protein called B-RAF, which is involved in sending signals in cells and in cell growth. This gene may be mutated (changed) in many types of cancer, which causes a change in the B-RAF protein. This can increase the growth and spread of cancer cells.

[edit] Further reading

Sithanandam G, Kolch W, Duh FM, Rapp UR (1991). "Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.". Oncogene 5 (12): 1775–80. PMID 2284096.
Garnett MJ, Marais R (2004). "Guilty as charged: B-RAF is a human oncogene.". Cancer Cell 6 (4): 313–9. doi:10.1016/j.ccr.2004.09.022. PMID 15488754.
Quiros RM, Ding HG, Gattuso P, et al. (2005). "Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations.". Cancer 103 (11): 2261–8. doi:10.1002/cncr.21073. PMID 15880523.
Karbowniczek M, Henske EP (2006). "The role of tuberin in cellular differentiation: are B-Raf and MAPK involved?". Ann. N. Y. Acad. Sci. 1059: 168–73. doi:10.1196/annals.1339.045. PMID 16382052.
Ciampi R, Nikiforov YE (2007). "RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis.". Endocrinology 148 (3): 936–41. doi:10.1210/en.2006-0921. PMID 16946010.
Espinosa AV, Porchia L, Ringel MD (2007). "Targeting BRAF in thyroid cancer.". Br. J. Cancer 96 (1): 16–20. doi:10.1038/sj.bjc.6603520. PMID 17179987.