Bone morphogenetic protein 8b

From Wikipedia, the free encyclopedia

This article or section contains too much jargon and may need simplification or further explanation. Please discuss this issue on the talk page, and/or remove or explain jargon terms used in the article. Editing help is available. This article has been tagged since January 2008.

Bone morphogenetic protein 8b
Other names:	Osteogenic Protein 2 (OP2)
Genetic data
Locus:	Chr. 1 p35-p32
Gene code:	HUGO code:BMP8b
Protein Structure/Function
Functions:	cell signaling, cell differentiation,cartilage development, growth, ossification
Domains:	TGFβ
Other
Taxa expressing:	many metazoan phyla
Cell types:	many (hippocampus)
Subcellular localization:	extracellular
Database Links
Entrez:	656
OMIM:	602284
RefSeq:	NM_001720
UniProt:	P34820

Bone morphogenetic protein 8b (BMP8b) is a polypeptide belonging to the TGF-β superfamily of proteins. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murine embryos.

v • d • e Cell signaling: TGF beta signaling pathway TGF beta superfamily of ligands TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) TGF beta receptors TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan Transducers/SMAD R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 Ligand Inhibitors Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 Coreceptors BAMBI - Cripto Other SARA