Bone morphogenetic protein 6

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Bone morphogenetic protein 6
Other names:	vegetal related growth factor (TGFB-related) (VGR1)
Genetic data
Locus:	Chr. 6 p24-p23
Gene code:	HUGO code:BMP6
Protein Structure/Function
Functions:	cell signaling, cell differentiation,cartilage development, growth, ossification
Domains:	TGFβ
Other
Taxa expressing:	many metazoan phyla
Cell types:	salivary gland, muscle, prostate, cartilage
Subcellular localization:	extracellular
Database Links
Entrez:	654
OMIM:	112266
RefSeq:	NM_001718
UniProt:	P22004

Bone morphogenetic protein 6 (BMP6) is a polypetide that is a member of the TGFβ superfamily of proteins. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.

v • d • e Cell signaling: TGF beta signaling pathway TGF beta superfamily of ligands TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) TGF beta receptors TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan Transducers/SMAD R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 Ligand Inhibitors Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 Coreceptors BAMBI - Cripto Other SARA