Bone morphogenetic protein 1

From Wikipedia, the free encyclopedia


Bone morphogenetic protein 1
Identifiers
Symbol(s) BMP1; FLJ44432; PCOLC; PCP; TLD
External IDs OMIM: 112264 MGI: 88176 HomoloGene: 55955
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 649 12153
Ensembl ENSG00000168487 ENSMUSG00000022098
Uniprot P13497 Q6P550
Refseq NM_001199 (mRNA)
NP_001190 (protein)		 NM_009755 (mRNA)
NP_033885 (protein)
Location Chr 8: 22.08 - 22.13 Mb Chr 14: 69.21 - 69.26 Mb
Pubmed search [1] [2]

Bone morphogenetic protein 1 (BMP1) is a protein that belongs to the peptidase M12A family of proteins. It induces bone and cartilage development. It is unlike other bone morphogenetic proteins since it does not belong to the TGFβ superfamily of proteins. It was initially discovered to work like other bone morphogenetic proteins by inducing bone and cartilage development. It however, is a metalloprotease that cleaves the C-terminus of procollagen I, II and III. It has an astacin-like protease domain.

It has been shown to cleave laminin 5 and is localized in the basal epithelial layer of bovine skin.

There are seven isoforms of the enzyme created by alternate splicing.

Bone morphogenetic protein 1, also known as BMP1, is a human gene.[1]

The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region[1]

[edit] References

  1. ^ a b Entrez Gene: BMP1 bone morphogenetic protein 1.

[edit] Further reading

  • Tabas JA, Zasloff M, Wasmuth JJ, et al. (1991). "Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3.". Genomics 9 (2): 283–9. PMID 2004778. 
  • Wozney JM, Rosen V, Celeste AJ, et al. (1989). "Novel regulators of bone formation: molecular clones and activities.". Science 242 (4885): 1528–34. PMID 3201241. 
  • Takahara K, Lyons GE, Greenspan DS (1995). "Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues.". J. Biol. Chem. 269 (51): 32572–8. PMID 7798260. 
  • Yoshiura K, Tamura T, Hong HS, et al. (1993). "Mapping of the bone morphogenetic protein 1 gene (BMP1) to 8p21: removal of BMP1 from candidacy for the bone disorder in Langer-Giedion syndrome.". Cytogenet. Cell Genet. 64 (3-4): 208–9. PMID 8404039. 
  • Takahara K, Lee S, Wood S, Greenspan DS (1996). "Structural organization and genetic localization of the human bone morphogenetic protein 1/mammalian tolloid gene.". Genomics 29 (1): 9–15. doi:10.1006/geno.1995.1209. PMID 8530106. 
  • Kessler E, Takahara K, Biniaminov L, et al. (1996). "Bone morphogenetic protein-1: the type I procollagen C-proteinase.". Science 271 (5247): 360–2. PMID 8553073. 
  • Li SW, Sieron AL, Fertala A, et al. (1996). "The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 5127–30. PMID 8643539. 
  • Janitz M, Heiser V, Böttcher U, et al. (1998). "Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1.". J. Mol. Med. 76 (2): 141–6. PMID 9500680. 
  • Scott IC, Blitz IL, Pappano WN, et al. (1999). "Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.". Dev. Biol. 213 (2): 283–300. doi:10.1006/dbio.1999.9383. PMID 10479448. 
  • Amano S, Scott IC, Takahara K, et al. (2000). "Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain.". J. Biol. Chem. 275 (30): 22728–35. doi:10.1074/jbc.M002345200. PMID 10806203. 
  • Scott IC, Blitz IL, Pappano WN, et al. (2001). "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling.". Nature 410 (6827): 475–8. doi:10.1038/35068572. PMID 11260715. 
  • Garrigue-Antar L, Barker C, Kadler KE (2001). "Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.". J. Biol. Chem. 276 (28): 26237–42. doi:10.1074/jbc.M010814200. PMID 11283002. 
  • Unsöld C, Pappano WN, Imamura Y, et al. (2002). "Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases.". J. Biol. Chem. 277 (7): 5596–602. doi:10.1074/jbc.M110003200. PMID 11741999. 
  • Rattenholl A, Pappano WN, Koch M, et al. (2002). "Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen.". J. Biol. Chem. 277 (29): 26372–8. doi:10.1074/jbc.M203247200. PMID 11986329. 
  • Garrigue-Antar L, Hartigan N, Kadler KE (2003). "Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein.". J. Biol. Chem. 277 (45): 43327–34. doi:10.1074/jbc.M207342200. PMID 12218058. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hartigan N, Garrigue-Antar L, Kadler KE (2003). "Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity.". J. Biol. Chem. 278 (20): 18045–9. doi:10.1074/jbc.M211448200. PMID 12637537. 
  • Leighton M, Kadler KE (2003). "Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network.". J. Biol. Chem. 278 (20): 18478–84. doi:10.1074/jbc.M213021200. PMID 12637569. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258. 

[edit] External links

 This article on a gene on chromosome 8 is a stub. You can help Wikipedia by expanding it.
v • d • e
Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins
Alpha secretases (ADAM9 · ADAM10 · ADAM17 · ADAM19) · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13
Matrix metalloproteinase
Other