BOK (gene)

From Wikipedia, the free encyclopedia

BCL2-related ovarian killer

Identifiers

BOK; BCL2L9; BOKL; MGC4631

External IDs

OMIM: 605404 MGI: 1858494 HomoloGene: 9632

Gene ontology
Molecular Function:	• protein dimerization activity
Cellular Component:	• cellular_component
Biological Process:	• induction of apoptosis • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_032515 (mRNA)
NP_115904 (protein)

NM_016778 (mRNA)
NP_058058 (protein)

Location

Chr 2: 242.15 - 242.16 Mb

Chr 1: 95.52 - 95.53 Mb

Pubmed search

[1]

[2]

BCL2-related ovarian killer, also known as BOK, is a human gene.^[1]

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains all four BCL-2 like domains (BH1, 2, 3 and 4) and is a pro-apoptotic BCL-2 protein identified in the ovary.^[1]

[edit] References

^ ^a ^b Entrez Gene: BOK BCL2-related ovarian killer.

[edit] Further reading

Hsu SY, Kaipia A, McGee E, et al. (1997). "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members.". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12401–6. PMID 9356461.
Inohara N, Ekhterae D, Garcia I, et al. (1998). "Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL.". J. Biol. Chem. 273 (15): 8705–10. PMID 9535847.
Leo CP, Hsu SY, Chun SY, et al. (1999). "Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary.". Endocrinology 140 (12): 5469–77. PMID 10579309.
Zhang H, Huang Q, Ke N, et al. (2000). "Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms.". J. Biol. Chem. 275 (35): 27303–6. doi:10.1074/jbc.M002846200. PMID 10811653.
Zhang H, Holzgreve W, De Geyter C (2000). "Evolutionarily conserved Bok proteins in the Bcl-2 family.". FEBS Lett. 480 (2-3): 311–3. PMID 11034351.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yakovlev AG, Di Giovanni S, Wang G, et al. (2004). "BOK and NOXA are essential mediators of p53-dependent apoptosis.". J. Biol. Chem. 279 (27): 28367–74. doi:10.1074/jbc.M313526200. PMID 15102863.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Soleymanlou N, Wu Y, Wang JX, et al. (2005). "A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia.". Cell Death Differ. 12 (5): 441–52. doi:10.1038/sj.cdd.4401593. PMID 15775999.
Gao S, Fu W, Dürrenberger M, et al. (2005). "Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3.". Cell. Mol. Life Sci. 62 (9): 1015–24. doi:10.1007/s00018-005-4543-3. PMID 15868100.
Bartholomeusz G, Wu Y, Ali Seyed M, et al. (2006). "Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.". Mol. Carcinog. 45 (2): 73–83. doi:10.1002/mc.20156. PMID 16302269.
Rodriguez JM, Glozak MA, Ma Y, Cress WD (2006). "Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and Sensitizes to Stress-induced Apoptosis.". J. Biol. Chem. 281 (32): 22729–35. doi:10.1074/jbc.M604705200. PMID 16772296.