BNIP3

From Wikipedia, the free encyclopedia


BCL2/adenovirus E1B 19kDa interacting protein 3
PDB rendering based on 2j5d.
Available structures: 2j5d
Identifiers
Symbol(s) BNIP3; NIP3
External IDs OMIM: 603293 MGI: 109326 HomoloGene: 2990
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 664 12176
Ensembl ENSG00000176171 n/a
Uniprot Q12983 n/a
Refseq NM_004052 (mRNA)
NP_004043 (protein)		 NM_009760 (mRNA)
NP_033890 (protein)
Location Chr 10: 133.63 - 133.65 Mb n/a
Pubmed search [1] [2]

BCL2/adenovirus E1B 19kDa interacting protein 3, also known as BNIP3, is a human gene.

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. This gene contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.[1]

[edit] References

  1. ^ Entrez Gene: BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3.

[edit] Further reading

  • Kataoka N, Ohno M, Moda I, Shimura Y (1995). "Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein.". Nucleic Acids Res. 23 (18): 3638–41. PMID 7478990. 
  • Boyd JM, Malstrom S, Subramanian T, et al. (1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.". Cell 79 (2): 341–51. PMID 7954800. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Chen G, Ray R, Dubik D, et al. (1998). "The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis.". J. Exp. Med. 186 (12): 1975–83. PMID 9396766. 
  • Yasuda M, Theodorakis P, Subramanian T, Chinnadurai G (1998). "Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence.". J. Biol. Chem. 273 (20): 12415–21. PMID 9575197. 
  • Chen G, Cizeau J, Vande Velde C, et al. (1999). "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins.". J. Biol. Chem. 274 (1): 7–10. PMID 9867803. 
  • Yasuda M, Han JW, Dionne CA, et al. (1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3.". Cancer Res. 59 (3): 533–7. PMID 9973195. 
  • Ohi N, Tokunaga A, Tsunoda H, et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.". Cell Death Differ. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623. 
  • Ray R, Chen G, Vande Velde C, et al. (2000). "BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites.". J. Biol. Chem. 275 (2): 1439–48. PMID 10625696. 
  • Vande Velde C, Cizeau J, Dubik D, et al. (2000). "BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore.". Mol. Cell. Biol. 20 (15): 5454–68. PMID 10891486. 
  • Lee SM, Li ML, Tse YC, et al. (2002). "Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway.". Life Sci. 71 (19): 2267–77. PMID 12215374. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lamy L, Ticchioni M, Rouquette-Jazdanian AK, et al. (2003). "CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis.". J. Biol. Chem. 278 (26): 23915–21. doi:10.1074/jbc.M301869200. PMID 12690108. 
  • Kothari S, Cizeau J, McMillan-Ward E, et al. (2003). "BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF.". Oncogene 22 (30): 4734–44. doi:10.1038/sj.onc.1206666. PMID 12879018. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
  • Okami J, Simeone DM, Logsdon CD (2004). "Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer.". Cancer Res. 64 (15): 5338–46. doi:10.1158/0008-5472.CAN-04-0089. PMID 15289340. 
  • Giatromanolaki A, Koukourakis MI, Sowter HM, et al. (2005). "BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer.". Clin. Cancer Res. 10 (16): 5566–71. doi:10.1158/1078-0432.CCR-04-0076. PMID 15328198. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Shen XY, Zacal N, Singh G, Rainbow AJ (2005). "Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells.". Photochem. Photobiol. 81 (2): 306–13. doi:10.1562/2004-07-22-RA-242. PMID 15560738. 
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