BNIP2

From Wikipedia, the free encyclopedia

BCL2/adenovirus E1B 19kDa interacting protein 2

Identifiers

BNIP2; BNIP-2; NIP2

External IDs

OMIM: 603292 MGI: 109327 HomoloGene: 3194

Gene ontology
Molecular Function:	• GTPase activator activity • calcium ion binding • protein binding
Cellular Component:	• nuclear envelope • cytoplasm • intracellular membrane-bound organelle
Biological Process:	• apoptosis • anti-apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004330 (mRNA)
NP_004321 (protein)

NM_001008238 (mRNA)
NP_001008239 (protein)

Location

Chr 15: 57.74 - 57.77 Mb

Chr 9: 69.79 - 69.81 Mb

Pubmed search

[1]

[2]

BCL2/adenovirus E1B 19kDa interacting protein 2, also known as BNIP2, is a human gene.^[1]

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector.^[1]

[edit] References

^ ^a ^b Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2.

[edit] Further reading

Belcredito S, Vegeto E, Brusadelli A, et al. (2002). "Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2.". Brain Res. Brain Res. Rev. 37 (1-3): 335-42. PMID 11744098.
Boyd JM, Malstrom S, Subramanian T, et al. (1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.". Cell 79 (2): 341-51. PMID 7954800.
Ohi N, Tokunaga A, Tsunoda H, et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.". Cell Death Differ. 6 (4): 314-25. doi:10.1038/sj.cdd.4400493. PMID 10381623.
Low BC, Lim YP, Lim J, et al. (2000). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42.". J. Biol. Chem. 274 (46): 33123-30. PMID 10551883.
Low BC, Seow KT, Guy GR (2000). "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2.". J. Biol. Chem. 275 (19): 14415-22. PMID 10799524.
Low BC, Seow KT, Guy GR (2001). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP.". J. Biol. Chem. 275 (48): 37742-51. doi:10.1074/jbc.M004897200. PMID 10954711.
Zhou YT, Soh UJ, Shang X, et al. (2002). "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence.". J. Biol. Chem. 277 (9): 7483-92. doi:10.1074/jbc.M109459200. PMID 11741952.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Qin W, Hu J, Guo M, et al. (2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.". Biochem. Biophys. Res. Commun. 308 (2): 379-85. PMID 12901880.
Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.". J. Biol. Chem. 278 (46): 45903-14. doi:10.1074/jbc.M304514200. PMID 12944407.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zhou YT, Guy GR, Low BC (2005). "BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain.". Exp. Cell Res. 303 (2): 263-74. doi:10.1016/j.yexcr.2004.08.044. PMID 15652341.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.