BNC1

From Wikipedia, the free encyclopedia

Basonuclin 1

Identifiers

BNC1; BNC; BSN1; HsT19447

External IDs

OMIM: 601930 MGI: 1097164 HomoloGene: 31048

Gene ontology
Molecular Function:	• nucleic acid binding • transcription factor activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • positive regulation of cell proliferation • epidermis development

Orthologs

Human

Mouse

n/a

n/a

Refseq

XM_001128055 (mRNA)
XP_001128055 (protein)

NM_007562 (mRNA)
NP_031588 (protein)

Location

n/a

Chr 7: 81.84 - 81.85 Mb

Pubmed search

[1]

[2]

Basonuclin 1, also known as BNC1, is a human gene.^[1]

The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: BNC1 basonuclin 1.

[edit] Further reading

Tseng H (1998). "Basonuclin, a zinc finger protein associated with epithelial expansion and proliferation.". Front. Biosci. 3: D985–8. PMID 9727087.
Tseng H, Green H (1992). "Basonuclin: a keratinocyte protein with multiple paired zinc fingers.". Proc. Natl. Acad. Sci. U.S.A. 89 (21): 10311–5. PMID 1332044.
Tseng H, Green H (1994). "Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.". J. Cell Biol. 126 (2): 495–506. PMID 8034748.
Teumer J, Tseng H, Green H (1997). "The human basonuclin gene.". Gene 188 (1): 1–7. PMID 9099851.
Yang Z, Gallicano GI, Yu QC, Fuchs E (1997). "An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids.". J. Cell Biol. 137 (3): 657–69. PMID 9151672.
Iuchi S, Green H (1997). "Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation.". Proc. Natl. Acad. Sci. U.S.A. 94 (15): 7948–53. PMID 9223293.
Mahoney MG, Tang W, Xiang MM, et al. (1998). "Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis.". Biol. Reprod. 59 (2): 388–94. PMID 9687312.
Iuchi S, Green H (1999). "Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9628–32. PMID 10449744.
Tseng H, Biegel JA, Brown RS (2000). "Basonuclin is associated with the ribosomal RNA genes on human keratinocyte mitotic chromosomes.". J. Cell. Sci. 112 Pt 18: 3039–47. PMID 10462520.
Tang W, Tseng H (1999). "A GC-rich sequence within the 5' untranslated region of human basonuclin mRNA inhibits its translation.". Gene 237 (1): 35–44. PMID 10524234.
Iuchi S, Easley K, Matsuzaki K, et al. (2000). "Alternative subcellular locations of keratinocyte basonuclin.". Exp. Dermatol. 9 (3): 178–84. PMID 10839715.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Chen L, Willis SN, Wei A, et al. (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.". Mol. Cell 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
Vanhoutteghem A, Djian P (2006). "Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.". Proc. Natl. Acad. Sci. U.S.A. 103 (33): 12423–8. doi:10.1073/pnas.0605086103. PMID 16891417.