BMP2K

From Wikipedia, the free encyclopedia

BMP2 inducible kinase

Identifiers

BMP2K; BIKE; DKFZp434K0614; DKFZp434P0116; HRIHFB2017

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017593 (mRNA)
NP_060063 (protein)

NM_080708 (mRNA)
NP_542439 (protein)

Location

Chr 4: 79.92 - 80.05 Mb

Chr 5: 97.24 - 97.33 Mb

Pubmed search

[1]

[2]

BMP2 inducible kinase, also known as BMP2K, is a human gene.^[1]

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: BMP2K BMP2 inducible kinase.

[edit] Further reading

Hoffmann A, Gross G (2002). "BMP signaling pathways in cartilage and bone formation.". Crit. Rev. Eukaryot. Gene Expr. 11 (1-3): 23-45. PMID 11693963.
Ueki N, Oda T, Kondo M, et al. (1999). "Selection system for genes encoding nuclear-targeted proteins.". Nat. Biotechnol. 16 (13): 1338-42. doi:10.1038/4315. PMID 9853615.
Kearns AE, Donohue MM, Sanyal B, Demay MB (2001). "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro.". J. Biol. Chem. 276 (45): 42213-8. doi:10.1074/jbc.M106163200. PMID 11500515.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Arikawa T, Omura K, Morita I (2004). "Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells.". J. Cell. Physiol. 200 (3): 400-6. doi:10.1002/jcp.20031. PMID 15254968.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Medici M, van Meurs JB, Rivadeneira F, et al. (2006). "BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study.". J. Bone Miner. Res. 21 (6): 845-54. doi:10.1359/jbmr.060306. PMID 16753015.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.