BMP15 (gene)

From Wikipedia, the free encyclopedia

Bone morphogenetic protein 15

Identifiers

BMP15; GDF9B; ODG2; POF4

External IDs

OMIM: 300247 MGI: 1316745 HomoloGene: 3977

Gene ontology
Molecular Function:	• cytokine activity • growth factor activity
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• female gamete generation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005448 (mRNA)
NP_005439 (protein)

NM_009757 (mRNA)
NP_033887 (protein)

Location

Chr X: 50.67 - 50.68 Mb

Chr X: 5.49 - 5.5 Mb

Pubmed search

[1]

[2]

Bone morphogenetic protein 15, also known as BMP15, is a human gene.^[1]

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.^[1]

[edit] References

^ ^a ^b Entrez Gene: BMP15 bone morphogenetic protein 15.

[edit] Further reading

Dube JL, Wang P, Elvin J, et al. (1999). "The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes.". Mol. Endocrinol. 12 (12): 1809–17. PMID 9849956.
Aaltonen J, Laitinen MP, Vuojolainen K, et al. (1999). "Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis.". J. Clin. Endocrinol. Metab. 84 (8): 2744–50. PMID 10443672.
Galloway SM, McNatty KP, Cambridge LM, et al. (2000). "Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner.". Nat. Genet. 25 (3): 279–83. doi:10.1038/77033. PMID 10888873.
Otsuka F, Yao Z, Lee T, et al. (2001). "Bone morphogenetic protein-15. Identification of target cells and biological functions.". J. Biol. Chem. 275 (50): 39523–8. doi:10.1074/jbc.M007428200. PMID 10998422.
Otsuka F, Moore RK, Iemura S, et al. (2002). "Follistatin inhibits the function of the oocyte-derived factor BMP-15.". Biochem. Biophys. Res. Commun. 289 (5): 961–6. doi:10.1006/bbrc.2001.6103. PMID 11741284.
Moore RK, Otsuka F, Shimasaki S (2003). "Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells.". J. Biol. Chem. 278 (1): 304–10. doi:10.1074/jbc.M207362200. PMID 12419820.
Liao WX, Moore RK, Otsuka F, Shimasaki S (2003). "Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep.". J. Biol. Chem. 278 (6): 3713–9. doi:10.1074/jbc.M210598200. PMID 12446716.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Liao WX, Moore RK, Shimasaki S (2004). "Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9.". J. Biol. Chem. 279 (17): 17391–6. doi:10.1074/jbc.M401050200. PMID 14970198.
Di Pasquale E, Beck-Peccoz P, Persani L (2004). "Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene.". Am. J. Hum. Genet. 75 (1): 106–11. doi:10.1086/422103. PMID 15136966.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Hashimoto O, Moore RK, Shimasaki S (2005). "Posttranslational processing of mouse and human BMP-15: potential implication in the determination of ovulation quota.". Proc. Natl. Acad. Sci. U.S.A. 102 (15): 5426–31. doi:10.1073/pnas.0409533102. PMID 15809424.
Dixit H, Rao LK, Padmalatha VV, et al. (2006). "Missense mutations in the BMP15 gene are associated with ovarian failure.". Hum. Genet. 119 (4): 408–15. doi:10.1007/s00439-006-0150-0. PMID 16508750.
Laissue P, Christin-Maitre S, Touraine P, et al. (2006). "Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure.". Eur. J. Endocrinol. 154 (5): 739–44. doi:10.1530/eje.1.02135. PMID 16645022.
Chand AL, Ponnampalam AP, Harris SE, et al. (2006). "Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure.". Fertil. Steril. 86 (4): 1009–12. doi:10.1016/j.fertnstert.2006.02.107. PMID 17027369.