BMI1

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BMI1 polycomb ring finger oncogene
PDB rendering based on 2ckl.
Available structures: 2ckl, 2h0d
Identifiers
Symbol(s) BMI1; MGC12685; PCGF4; RNF51
External IDs OMIM: 164831 MGI: 88174 HomoloGene: 3797
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 648 12151
Ensembl ENSG00000168283 ENSMUSG00000026739
Uniprot P35226 Q2LC58
Refseq NM_005180 (mRNA)
NP_005171 (protein)		 XM_982861 (mRNA)
XP_987955 (protein)
Location Chr 10: 22.65 - 22.66 Mb Chr 2: 18.59 - 18.6 Mb
Pubmed search [1] [2]

BMI1 polycomb ring finger oncogene, also known as BMI1, is a human gene.


  • Alkema MJ, van der Lugt NM, Bobeldijk RC, et al. (1995). "Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice.". Nature 374 (6524): 724–7. doi:10.1038/374724a0. PMID 7715727. 
  • Alkema MJ, Wiegant J, Raap AK, et al. (1994). "Characterization and chromosomal localization of the human proto-oncogene BMI-1.". Hum. Mol. Genet. 2 (10): 1597–603. PMID 8268912. 
  • Levy LS, Lobelle-Rich PA, Overbaugh J (1993). "flvi-2, a target of retroviral insertional mutagenesis in feline thymic lymphosarcomas, encodes bmi-1.". Oncogene 8 (7): 1833–8. PMID 8390036. 
  • Alkema MJ, Bronk M, Verhoeven E, et al. (1997). "Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.". Genes Dev. 11 (2): 226–40. PMID 9009205. 
  • Gunster MJ, Satijn DP, Hamer KM, et al. (1997). "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.". Mol. Cell. Biol. 17 (4): 2326–35. PMID 9121482. 
  • Satijn DP, Gunster MJ, van der Vlag J, et al. (1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.". Mol. Cell. Biol. 17 (7): 4105–13. PMID 9199346. 
  • Alkema MJ, Jacobs J, Voncken JW, et al. (1997). "MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.". J. Mol. Biol. 273 (5): 993–1003. doi:10.1006/jmbi.1997.1372. PMID 9367786. 
  • Satijn DP, Otte AP (1999). "RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity.". Mol. Cell. Biol. 19 (1): 57–68. PMID 9858531. 
  • Voncken JW, Schweizer D, Aagaard L, et al. (2000). "Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status.". J. Cell. Sci. 112 ( Pt 24): 4627–39. PMID 10574711. 
  • Bárdos JI, Saurin AJ, Tissot C, et al. (2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties.". J. Biol. Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164. 
  • Trimarchi JM, Fairchild B, Wen J, Lees JA (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex.". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1519–24. doi:10.1073/pnas.041597698. PMID 11171983. 
  • Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.". Mol. Cell. Biol. 22 (17): 6070–8. PMID 12167701. 
  • Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.". Development 129 (18): 4171–83. PMID 12183370. 
  • Dimri GP, Martinez JL, Jacobs JJ, et al. (2002). "The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells.". Cancer Res. 62 (16): 4736–45. PMID 12183433. 
  • Barna M, Merghoub T, Costoya JA, et al. (2002). "Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling.". Dev. Cell 3 (4): 499–510. PMID 12408802. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cmarko D, Verschure PJ, Otte AP, et al. (2003). "Polycomb group gene silencing proteins are concentrated in the perichromatin compartment of the mammalian nucleus.". J. Cell. Sci. 116 (Pt 2): 335–43. PMID 12482919. 
  • Itahana K, Zou Y, Itahana Y, et al. (2003). "Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.". Mol. Cell. Biol. 23 (1): 389–401. PMID 12482990. 
  • Park IK, Qian D, Kiel M, et al. (2003). "Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.". Nature 423 (6937): 302–5. doi:10.1038/nature01587. PMID 12714971. 
  • Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ (2003). "MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein.". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8342–7. doi:10.1073/pnas.1436338100. PMID 12829790. 
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