BMF (gene)

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Bcl2 modifying factor
Identifiers
Symbol(s) BMF; FLJ00065
External IDs OMIM: 606266 MGI: 2176433 HomoloGene: 14130
Orthologs
Human Mouse
Entrez 90427 171543
Ensembl ENSG00000104081 ENSMUSG00000040093
Uniprot Q96LC9 Q3TAQ6
Refseq NM_001003940 (mRNA)
NP_001003940 (protein)		 NM_138313 (mRNA)
NP_612186 (protein)
Location Chr 15: 38.17 - 38.19 Mb Chr 2: 118.22 - 118.24 Mb
Pubmed search [1] [2]

Bcl2 modifying factor, also known as BMF, is a human gene.[1]

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

[edit] References

  1. ^ a b Entrez Gene: BMF Bcl2 modifying factor.

[edit] Further reading

  • Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen.". DNA Res. 7 (6): 357–66. PMID 11214971. 
  • Puthalakath H, Villunger A, O'Reilly LA, et al. (2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.". Science 293 (5536): 1829–32. doi:10.1126/science.1062257. PMID 11546872. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lei K, Davis RJ (2003). "JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2432–7. doi:10.1073/pnas.0438011100. PMID 12591950. 
  • Day CL, Puthalakath H, Skea G, et al. (2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.". Biochem. J. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMID 14561217. 
  • Morales AA, Olsson A, Celsing F, et al. (2004). "Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells.". Leukemia 18 (1): 41–7. doi:10.1038/sj.leu.2403183. PMID 14574334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Chen L, Willis SN, Wei A, et al. (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.". Mol. Cell 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340. 
  • Kuwana T, Bouchier-Hayes L, Chipuk JE, et al. (2005). "BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.". Mol. Cell 17 (4): 525–35. doi:10.1016/j.molcel.2005.02.003. PMID 15721256. 
  • Soung YH, Lee JW, Park WS, et al. (2006). "BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder.". Pathology 38 (1): 33–4. doi:10.1080/00313020500455811. PMID 16484005. 
  • Zhang Y, Adachi M, Kawamura R, et al. (2007). "Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation.". Apoptosis 11 (8): 1349–57. doi:10.1007/s10495-006-8266-1. PMID 16830229. 
  • Schmelzle T, Mailleux AA, Overholtzer M, et al. (2007). "Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 3787–92. doi:10.1073/pnas.0700115104. PMID 17360431. 
  • Yoo NJ, Soung YH, Lee SH, et al. (2007). "Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas.". Tumori 93 (2): 195–7. PMID 17557568. 
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