Blocking antibody

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A blocking antibody is an antibody that does not have a reaction when combined with an antigen, but prevents other antibodies from combining with that antigen. That is, it can either interferes with the reactivity of the others by binding available epitopes of homologous specificity or, univalent antibody that can coat antigen bearing cells but not agglutinate them. It also can refer to an immunoglobulin that combines specifically with an atopic allergen but does not elicit an allergic reaction.

The term can also be used for inhibiting antibody, prozone phenomenon and, agglutination reaction.