BLMH

From Wikipedia, the free encyclopedia

Bleomycin hydrolase

PDB rendering based on 1cb5.

Available structures: 1cb5, 2cb5

Identifiers

Symbol(s)

BLMH; BH; BMH

External IDs

OMIM: 602403 MGI: 1345186 HomoloGene: 330

Gene ontology
Molecular Function:	• aminopeptidase activity • carboxypeptidase activity • bleomycin hydrolase activity
Cellular Component:	• soluble fraction • nucleus • cytoplasm
Biological Process:	• proteolysis • response to toxin • response to drug

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000386 (mRNA)
NP_000377 (protein)

NM_178645 (mRNA)
NP_848760 (protein)

Location

Chr 17: 25.6 - 25.64 Mb

Chr 11: 76.76 - 76.8 Mb

Pubmed search

[1]

[2]

Bleomycin hydrolase, also known as BLMH, is a human gene.^[1]

Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.^[1]

[edit] References

^ ^a ^b Entrez Gene: BLMH bleomycin hydrolase.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Ferrando AA, Velasco G, Campo E, Lopez-Otin C (1996). "Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.". Cancer Res. 56 (8): 1746–50. PMID 8620487.
Brömme D, Rossi AB, Smeekens SP, et al. (1996). "Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization.". Biochemistry 35 (21): 6706–14. doi:10.1021/bi960092y. PMID 8639621.
Montoya SE, Ferrell RE, Lazo JS (1997). "Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase.". Cancer Res. 57 (19): 4191–5. PMID 9331073.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Ferrando AA, Pendás AM, Llano E, et al. (1998). "Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase.". J. Biol. Chem. 272 (52): 33298–304. PMID 9407121.
Koldamova RP, Lefterov IM, Gadjeva VG, Lazo JS (1998). "Essential binding and functional domains of human bleomycin hydrolase.". Biochemistry 37 (8): 2282–90. doi:10.1021/bi9722204. PMID 9485374.
Montoya SE, Aston CE, DeKosky ST, et al. (1998). "Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease.". Nat. Genet. 18 (3): 211–2. doi:10.1038/ng0398-211. PMID 9500538.
Zheng W, Johnston SA, Joshua-Tor L (1998). "The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase.". Cell 93 (1): 103–9. PMID 9546396.
Koldamova RP, Lefterov IM, DiSabella MT, Lazo JS (1999). "An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9.". Mol. Pharmacol. 54 (6): 954–61. PMID 9855622.
Takeda A, Nonaka M, Ishikawa A, Higuchi D (1999). "Immunohistochemical localization of the neutral cysteine protease bleomycin hydrolase in human skin.". Arch. Dermatol. Res. 291 (4): 238–40. PMID 10335922.
Koldamova RP, Lefterov IM, DiSabella MT, et al. (1999). "Human bleomycin hydrolase binds ribosomal proteins.". Biochemistry 38 (22): 7111–7. doi:10.1021/bi990135l. PMID 10353821.
O'Farrell PA, Gonzalez F, Zheng W, et al. (1999). "Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.". Structure 7 (6): 619–27. PMID 10404591.
Malherbe P, Faull RL, Richards JG (2000). "Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains.". Neurosci. Lett. 281 (1): 37–40. PMID 10686410.
Lefterov IM, Koldamova RP, Lazo JS (2000). "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein.". FASEB J. 14 (12): 1837–47. PMID 10973933.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nivet-Antoine V, Coulhon MP, Le Denmat C, et al. (2003). "[Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases]". Ann. Biol. Clin. (Paris) 61 (1): 61–7. PMID 12604387.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.