BLK (gene)

From Wikipedia, the free encyclopedia

B lymphoid tyrosine kinase

Identifiers

BLK; MGC10442

External IDs

OMIM: 191305 MGI: 88169 HomoloGene: 1297

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • protein binding • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • protein kinase cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001715 (mRNA)
NP_001706 (protein)

NM_007549 (mRNA)
NP_031575 (protein)

Location

Chr 8: 11.39 - 11.46 Mb

Chr 14: 62.33 - 62.37 Mb

Pubmed search

[1]

[2]

B lymphoid tyrosine kinase, also known as BLK, is a human gene.^[1]

[edit] References

^ Entrez Gene: BLK B lymphoid tyrosine kinase.

[edit] Further reading

Dymecki SM, Niederhuber JE, Desiderio SV (1990). "Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.". Science 247 (4940): 332–6. PMID 2404338.
Lin YH, Shin EJ, Campbell MJ, Niederhuber JE (1995). "Transcription of the blk gene in human B lymphocytes is controlled by two promoters.". J. Biol. Chem. 270 (43): 25968–75. PMID 7592787.
Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells.". J. Biol. Chem. 270 (45): 27072–8. PMID 7592958.
Islam KB, Rabbani H, Larsson C, et al. (1995). "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.". J. Immunol. 154 (3): 1265–72. PMID 7822795.
Drebin JA, Hartzell SW, Griffin C, et al. (1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk).". Oncogene 10 (3): 477–86. PMID 7845672.
Donovan JA, Wange RL, Langdon WY, Samelson LE (1994). "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.". J. Biol. Chem. 269 (37): 22921–4. PMID 8083187.
Pleiman CM, Clark MR, Gauen LK, et al. (1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.". Mol. Cell. Biol. 13 (9): 5877–87. PMID 8395016.
Malek SN, Yang CH, Earnshaw WC, et al. (1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains.". J. Biol. Chem. 271 (12): 6952–62. PMID 8636124.
Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.". Mol. Cell. Biol. 16 (9): 4735–43. PMID 8756631.
Saouaf SJ, Wolven A, Resh MD, Bolen JB (1997). "Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate.". Biochem. Biophys. Res. Commun. 234 (2): 325–9. doi:10.1006/bbrc.1997.6638. PMID 9177269.
Hegde R, Srinivasula SM, Ahmad M, et al. (1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.". J. Biol. Chem. 273 (14): 7783–6. PMID 9525867.
Oda H, Kumar S, Howley PM (1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. PMID 10449731.
Appel S, Filter M, Reis A, et al. (2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759.". Eur. J. Hum. Genet. 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. PMID 11896452.
Lee S, Ha S, Chung M, et al. (2003). "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells.". Cancer Lett. 188 (1-2): 121–6. PMID 12406557.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.