Blasticidin-S deaminase

From Wikipedia, the free encyclopedia

In enzymology, a blasticidin-S deaminase (EC 3.5.4.23) is an enzyme that catalyzes the chemical reaction

blasticidin S + H₂O deaminohydroxyblasticidin S + NH₃

Thus, the two substrates of this enzyme are blasticidin S and H₂O, whereas its two products are deaminohydroxyblasticidin S and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is blasticidin-S aminohydrolase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WN5 and 1WN6.

[edit] References

• IUBMB entry for 3.5.4.23
• BRENDA references for 3.5.4.23 (Recommended.)
• PubMed references for 3.5.4.23
• PubMed Central references for 3.5.4.23
• Google Scholar references for 3.5.4.23
• Yamaguchi I, Shibata H, Seto H, Misato T (Tokyo). "Isolation and purification of blasticidin S deaminase from Aspergillus terreus". J. Antibiot.: 7–14. PMID 236272. 

[edit] External links

The CAS registry number for this enzyme class is 54576-55-5.

• IUBMB entry for 3.5.4.23

• KEGG entry for 3.5.4.23

• BRENDA entry for 3.5.4.23

• NiceZyme view of 3.5.4.23

• EC2PDB: PDB structures for 3.5.4.23

• PRIAM entry for 3.5.4.23

• PUMA2 entry for 3.5.4.23

• IntEnz: Integrated Enzyme entry for 3.5.4.23

• MetaCyc entry for 3.5.4.23

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047711: blasticidin-S deaminase

• AMIGO entry for GO code 0047711: blasticidin-S deaminase