Bisoctrizole

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Bisoctrizole
Bisoctrizole
IUPAC name 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)

-4-(1,1,3,3-tetramethylbutyl)phenol]
Identifiers
CAS number [103597-45-l]
Properties
Molecular formula C41H50N6O2
Molar mass 658.89 g/mol
Melting point

195.7 °C
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Bisoctrizole (USAN[1], Tinosorb M, INCI Methylene Bis-Benzotriazolyl Tetramethylbutylphenol) is a benzotriazole based organic compound which is added to sunscreens to absorb UV rays. It is marketed by Ciba Specialty Chemicals.

Bisoctrizole is a broad spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. It also reflects and scatters UV. Bisoctrizole is a hybrid UV absorber. It's produced as small particles (< 200 nm)[2], like microfine zinc oxide and titanium dioxide. And it is organic like most sunscreen actives. It is added to the water phase of a sunscreen as a 50% suspension, while mineral micropigments are usually added to the oil phase.

Bisoctrizole shows very little photodegradation and has a stabilizing effect on other UV absorbers, octyl methoxycinnamate (octinoxate) in particular.

When formulated into a sunscreen bisoctrizole has minimal skin penetration.[3] Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro.[4]

Bisoctrizole is not approved by the FDA, but is approved in the EU and other parts of the world.[5][6][7]

[edit] See also

[edit] References

  1. ^ http://www.ama-assn.org/ama1/pub/upload/mm/365/bisoctrizol.doc
  2. ^ Blackwell Synergy - Int J Cosmet Sci, Volume 24 Issue 3 Page 170-185, June 2002 (Article Abstract)
  3. ^ Mavon A, Miquel C, Lejeune O, Payre B, Moretto P (2007). "In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen". Skin Pharmacol Physiol 20(1): 10–20. doi:10.1159/000096167. PMID 17035717. 
  4. ^ Ashby J, Tinwell H, Plautz J, Twomey K, Lefevre PA (Dec 2001). "Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S". Regul Toxicol Pharmacol 34(3): 287–91. doi:10.1006/rtph.2001.1511. PMID 11754532. 
  5. ^ Manage Account - Modern Medicine
  6. ^ CL1976L0768EN0150010.0001 1..107
  7. ^ Australian Regulatory Guidelines for OTC Medicines - Chapter 10

[edit] External links

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