Bisacodyl

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Bisacodyl
Systematic (IUPAC) name
[4-[(4-acetyloxyphenyl)-pyridin-2-yl-methyl]phenyl] acetate
Identifiers
CAS number	603-50-9
ATC code	A06AB02
PubChem	2391
Chemical data
Formula	C22H19NO4
Mol. mass	361.39
Pharmacokinetic data
Bioavailability	15%
Metabolism	Hepatic CYP450
Half life	16 Hours
Excretion	primarily in the faeces, systemically absorbed drug is excreted in the urine
Therapeutic considerations
Pregnancy cat.	C
Legal status	OTC
Routes	Oral, Rectal

Bisacodyl (INN) is a stimulant laxative drug. It is typically prescribed for relief of constipation and for the management of neurogenic bowel dysfunction. Bisacodyl is a diphenylmethane derivative and was first used as a laxative in 1953 due to its similarity to phenolphthalein [1].

Contents 1 Available forms 2 Administration 3 References 4 External links

[edit] Available forms

Bisacodyl is sold under the trade names Dulcolax, Fleet, Alophen, Correctol, Carter's Little Pills as well as generically. It is usually sold as 5mg tablets, 10mg suppositories, or 5mg pediatric suppositories.

[edit] Administration

When bisacodyl is administered orally, it is usually taken at bedtime, but when it is administered rectally, it is usually taken in the morning. This is due to the relatively long onset of the drug when taken orally (around 6-10 hours) compared to when it is taken rectally (around 15-60 minutes). This drug is often used by people suffering from bulimia nervosa. The largest amount of this drug known to be taken at one time and not to cause any serious health disorders is 180 5mg tablets (the total amount of drug intake equal to 900mg).^[1]

[edit] References

1. ^ Wexner, SD; Beck, DE; Baron, TH; Fanelli, RD; Hyman, N; Shen, B; Wasco, KE; American Society of Colon and Rectal Surgeons; American Society for Gastrointestinal Endoscopy; Society of American Gastrointestinal and Endoscopic Surgeons (Jun 2006). "A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES)". Gastrointest Endosc. 63 (7): 894–909. ISSN 0016-5107. PMID 16733101. 

[edit] External links

• Bisacodyl at drugdigest.org
• Bowel care with bisacodyl suppositories
• bisacodyl Consumer Drug Information
• Dulcolax laxative

v • d • e Laxatives (A06) Softeners, emollients Paraffin - Docusate sodium Contact laxatives Oxyphenisatine - Bisacodyl - Dantron - Phenolphthalein - Castor oil - Senna glycosides - Cascara - Sodium picosulfate - Bisoxatin Bulk producers Ispaghula - Ethulose - Sterculia - Linseed - Methylcellulose - Triticum - Polycarbophil calcium Osmotically acting laxatives Magnesium carbonate - Magnesium oxide - Magnesium peroxide - Magnesium sulfate - Lactulose - Lactitol - Sodium sulfate - Pentaerithrityl - Macrogol - Mannitol - Sodium phosphate - Sorbitol - Magnesium citrate - Sodium tartrate Enemas Sodium phosphate - Bisacodyl - Dantron - Glycerol - Oil - Sorbitol