Bis-gamma-glutamylcystine reductase

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In enzymology, a bis-gamma-glutamylcystine reductase (EC 1.8.1.13) is an enzyme that catalyzes the chemical reaction

2 gamma-glutamylcysteine + NADP⁺ $\rightleftharpoons$ bis-gamma-glutamylcystine + NADPH + H⁺

Thus, the two substrates of this enzyme are gamma-glutamylcysteine and NADP⁺, whereas its 3 products are bis-gamma-glutamylcystine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is gamma-glutamylcysteine:NADP+ oxidoreductase. This enzyme is also called NADPH2:bis-gamma-glutamylcysteine oxidoreductase. This enzyme participates in glutathione metabolism.

[edit] References

IUBMB entry for 1.8.1.13
BRENDA references for 1.8.1.13 (Recommended.)
PubMed references for 1.8.1.13
PubMed Central references for 1.8.1.13
Google Scholar references for 1.8.1.13
Sundquist AR, Fahey RC (1988). "The novel disulfide reductase bis-gamma-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes". J. Bacteriol. 170: 3459–67. PMID 3136140.
Sundquist AR, Fahey RC (1989). "The function of gamma-glutamylcysteine and bis-gamma-glutamylcystine reductase in Halobacterium halobium". J. Biol. Chem. 264: 719–25. PMID 2910862.