BIRC6

From Wikipedia, the free encyclopedia

Baculoviral IAP repeat-containing 6 (apollon)

Identifiers

BIRC6; APOLLON; BRUCE; FLJ13726; FLJ13786; KIAA1289

External IDs

OMIM: 605638 MGI: 1276108 HomoloGene: 7248

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • cysteine protease inhibitor activity • ligase activity
Cellular Component:	• cellular_component • intracellular
Biological Process:	• ubiquitin cycle • apoptosis • anti-apoptosis

Orthologs

Human

Mouse

n/a

Refseq

NM_016252 (mRNA)
NP_057336 (protein)

NM_007566 (mRNA)
NP_031592 (protein)

Location

Chr 2: 32.44 - 32.7 Mb

Chr 17: 74.43 - 74.61 Mb

Pubmed search

[1]

[2]

Baculoviral IAP repeat-containing 6 (apollon), also known as BIRC6, is a human gene.^[1]

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.^[1]

[edit] References

^ ^a ^b Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon).

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Chen Z, Naito M, Hori S, et al. (1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells.". Biochem. Biophys. Res. Commun. 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. PMID 10574462.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Qiu XB, Markant SL, Yuan J, Goldberg AL (2005). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMID 14765125.
Bartke T, Pohl C, Pyrowolakis G, Jentsch S (2005). "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.". Mol. Cell 14 (6): 801–11. doi:10.1016/j.molcel.2004.05.018. PMID 15200957.
Hao Y, Sekine K, Kawabata A, et al. (2004). "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function.". Nat. Cell Biol. 6 (9): 849–60. doi:10.1038/ncb1159. PMID 15300255.
Wu X, Yen L, Irwin L, et al. (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMID 15314180.
Qiu XB, Goldberg AL (2005). "The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9.". J. Biol. Chem. 280 (1): 174–82. doi:10.1074/jbc.M411430200. PMID 15507451.