Bip internal ribosome entry site (IRES)

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bip internal ribosome entry site (IRES)

Type:	Cis-reg; IRES;
2° structure:	Predicted; PFOLD
Seed alignment:	http://ifr31w3.toulouse.inserm.fr/IRESdatabase/
Avg length:	236.4 nucleotides
Avg identity:	74%

The BiP internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of BiP protein and allows cap-independent translation. BiP protein expression has been found to be significantly enhanced by the heat shock response due to internal ribosome entry site (IRES)-dependent translation. It is thought that this translational mechanism is essential for the survival of cells under stress [1].

[edit] References

[1] Kim, YK; Jang SK (2002). "Continuous heat shock enhances translational initiation directed by internal ribosomal entry site". Biochem Biophys Res Commun 297: 224–231. doi:10.1016/S0006-291X(02)02154-X. PMID 12237106.