Biotin carboxylase
From Wikipedia, the free encyclopedia
In enzymology, a biotin carboxylase (EC 6.3.4.14) is an enzyme that catalyzes the chemical reaction
- ATP + biotin-carboxyl-carrier protein + CO2
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
The 3 substrates of this enzyme are ATP, biotin-carboxyl-carrier protein, and CO2, whereas its 3 products are ADP, phosphate, and carboxybiotin-carboxyl-carrier protein.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming). This enzyme is also called biotin carboxylase (component of acetyl CoA carboxylase). This enzyme participates in fatty acid biosynthesis.
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[edit] Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1BNC, 1DV1, 1DV2, 2GPS, and 2GPW.
[edit] References
- IUBMB entry for 6.3.4.14
- BRENDA references for 6.3.4.14 (Recommended.)
- PubMed references for 6.3.4.14
- PubMed Central references for 6.3.4.14
- Google Scholar references for 6.3.4.14
- Dimroth P, Guchhait RB, Stoll E, Lane MD (1970). "Enzymatic carboxylation of biotin: molecular and catalytic properties of a component enzyme of acetyl CoA carboxylase". Proc. Natl. Acad. Sci. U. S. A. 67: 1353–60. doi:. PMID 4922289.
[edit] External links
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- The CAS registry number for this enzyme class is 9075-71-2.
[edit] Gene Ontology (GO) codes
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