Biotin-(acetyl-CoA-carboxylase) ligase

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In enzymology, a biotin-[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15) is an enzyme that catalyzes the chemical reaction

ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] \rightleftharpoons AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

The 3 substrates of this enzyme are ATP, biotin, and [[apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)]]], whereas its 3 products are AMP, diphosphate, and [[[acetyl-CoA:carbon-dioxide ligase (ADP-forming)]]].

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include biotin-[acetyl-CoA carboxylase] synthetase, biotin-[acetyl coenzyme A carboxylase] synthetase, acetyl coenzyme A holocarboxylase synthetase, acetyl CoA holocarboxylase synthetase, biotin:apocarboxylase ligase, Biotin holoenzyme synthetase, and HCS. This enzyme participates in biotin metabolism.

Contents

[edit] Structural studies

As of late 2007, 29 structures have been solved for this class of enzymes, with PDB accession codes 1BIA, 1BIB, 1HXD, 1WNL, 1WPY, 1WQ7, 1WQW, 1X01, 2CGH, 2DEQ, 2DJZ, 2DKG, 2DTH, 2DTI, 2DTO, 2DVE, 2DXT, 2DXU, 2DZ9, 2DZC, 2E10, 2E3Y, 2E41, 2E64, 2E65, 2EAY, 2EWN, 2FYK, and 2HNI.

[edit] References

[edit] External links

The CAS registry number for this enzyme class is 37340-95-7.

[edit] Gene Ontology (GO) codes

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