Bile-acid 7alpha-dehydratase

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In enzymology, a bile-acid 7alpha-dehydratase (EC 4.2.1.106) is an enzyme that catalyzes the chemical reaction

7alpha,12alpha-dihydroxy-3-oxochol-4-enoate 12alpha-hydroxy-3-oxochola-4,6-dienoate + H₂O

Hence, this enzyme has one substrate, 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate, and two products, 12alpha-hydroxy-3-oxochola-4,6-dienoate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming). This enzyme is also called 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase.

[edit] References

• IUBMB entry for 4.2.1.106
• BRENDA references for 4.2.1.106 (Recommended.)
• PubMed references for 4.2.1.106
• PubMed Central references for 4.2.1.106
• Google Scholar references for 4.2.1.106
• Dawson JA, Mallonee DH, Bjorkhem I, Hylemon PB (1996). "Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli". J. Lipid. Res. 37: 1258–67. PMID 8808760. 

[edit] External links

• IUBMB entry for 4.2.1.106

• KEGG entry for 4.2.1.106

• BRENDA entry for 4.2.1.106

• NiceZyme view of 4.2.1.106

• EC2PDB: PDB structures for 4.2.1.106

• PRIAM entry for 4.2.1.106

• PUMA2 entry for 4.2.1.106

• IntEnz: Integrated Enzyme entry for 4.2.1.106

• MetaCyc entry for 4.2.1.106

• Atomic-resolution structures of enzymes belonging to this class