BICD1

From Wikipedia, the free encyclopedia

Bicaudal D homolog 1 (Drosophila)

Identifiers

External IDs

OMIM: 602204 MGI: 1101760 HomoloGene: 37518

Gene ontology
Molecular Function:	• structural constituent of cytoskeleton
Cellular Component:	• cytoskeleton
Biological Process:	• RNA processing • intracellular mRNA localization • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001003398 (mRNA)
NP_001003398 (protein)

NM_009753 (mRNA)
NP_033883 (protein)

Location

Chr 12: 32.15 - 32.42 Mb

Chr 6: 149.37 - 149.48 Mb

Pubmed search

[1]

[2]

Bicaudal D homolog 1 (Drosophila), also known as BICD1, is a human gene.^[1]

This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila).

[edit] Further reading

Barr FA, Short B (2004). "Golgins in the structure and dynamics of the Golgi apparatus.". Curr. Opin. Cell Biol. 15 (4): 405-13. PMID 12892780.
Claussen M, Suter B (2006). "BicD-dependent localization processes: from Drosophilia development to human cell biology.". Ann. Anat. 187 (5-6): 539-53. PMID 16320833.
Baens M, Aerssens J, van Zand K, et al. (1996). "Isolation and regional assignment of human chromosome 12p cDNAs.". Genomics 29 (1): 44-52. doi:10.1006/geno.1995.1213. PMID 8530100.
Baens M, Marynen P (1998). "A human homologue (BICD1) of the Drosophila bicaudal-D gene.". Genomics 45 (3): 601-6. doi:10.1006/geno.1997.4971. PMID 9367685.
Short B, Preisinger C, Schaletzky J, et al. (2003). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes.". Curr. Biol. 12 (20): 1792-5. PMID 12401177.
Matanis T, Akhmanova A, Wulf P, et al. (2003). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex.". Nat. Cell Biol. 4 (12): 986-92. doi:10.1038/ncb891. PMID 12447383.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.". J. Biol. Chem. 278 (12): 10048-54. doi:10.1074/jbc.M212632200. PMID 12522145.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Fuchs E, Short B, Barr FA (2006). "Assay and properties of rab6 interaction with dynein-dynactin complexes.". Meth. Enzymol. 403: 607-18. doi:10.1016/S0076-6879(05)03053-3. PMID 16473624.
Moorhead AR, Rzomp KA, Scidmore MA (2007). "The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner.". Infect. Immun. 75 (2): 781-91. doi:10.1128/IAI.01447-06. PMID 17101644.
Fumoto K, Hoogenraad CC, Kikuchi A (2007). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.". EMBO J. 25 (24): 5670-82. doi:10.1038/sj.emboj.7601459. PMID 17139249.
Wanschers BF, van de Vorstenbosch R, Schlager MA, et al. (2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells.". Exp. Cell Res. 313 (16): 3408-20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.