BHLHB8

From Wikipedia, the free encyclopedia

Basic helix-loop-helix domain containing, class B, 8

Identifiers

External IDs

OMIM: 608606 MGI: 891976 HomoloGene: 7838

Gene ontology
Molecular Function:	• DNA binding • transcription regulator activity • protein homodimerization activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • mitochondrial calcium ion transport • Golgi organization and biogenesis • G-protein coupled receptor protein signaling pathway • cell-cell signaling • calcium-mediated signaling • glucose homeostasis • positive regulation of transcription from RNA polymerase II promoter • intracellular distribution of mitochondria • cell maturation

Orthologs

Human

Mouse

Refseq

NM_177455 (mRNA)
NP_803238 (protein)

NM_010800 (mRNA)
NP_034930 (protein)

Location

Chr 7: 97.68 - 97.68 Mb

Chr 5: 144.44 - 144.45 Mb

Pubmed search

[1]

[2]

Basic helix-loop-helix domain containing, class B, 8, also known as BHLHB8, is a human gene.^[1]

[edit] References

^ Entrez Gene: BHLHB8 basic helix-loop-helix domain containing, class B, 8.

[edit] Further reading

Lemercier C, To RQ, Swanson BJ, et al. (1997). "Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern.". Dev. Biol. 182 (1): 101–13. doi:10.1006/dbio.1996.8454. PMID 9073453.
Lemercier C, To RQ, Carrasco RA, Konieczny SF (1998). "The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD.". EMBO J. 17 (5): 1412–22. doi:10.1093/emboj/17.5.1412. PMID 9482738.
Pin CL, Lemercier C, Konieczny SF (2000). "Cloning of the murine Mist1 gene and assignment to mouse chromosome band 5G2-5G3.". Cytogenet. Cell Genet. 86 (3-4): 219–22. PMID 10575209.
Pin CL, Rukstalis JM, Johnson C, Konieczny SF (2001). "The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.". J. Cell Biol. 155 (4): 519–30. doi:10.1083/jcb.200105060. PMID 11696558.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
McLellan AS, Langlands K, Kealey T (2003). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.". Gene Expr. Patterns 2 (3-4): 329–35. PMID 12617822.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
McLellan AS, Langlands K, Kealey T. "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.". Mech. Dev. 119 Suppl 1: S285–91. PMID 14516699.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhao Y, Johansson C, Tran T, et al. (2006). "Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for maintenance of the differentiated state.". Mol. Endocrinol. 20 (9): 2187–98. doi:10.1210/me.2005-0214. PMID 16645041.