BHLHB3

From Wikipedia, the free encyclopedia

Basic helix-loop-helix domain containing, class B, 3

Identifiers

BHLHB3; DEC2; SHARP-1; SHARP1

External IDs

OMIM: 606200 MGI: 1930704 HomoloGene: 11549

Gene ontology
Molecular Function:	• transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • cell proliferation • organ morphogenesis • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030762 (mRNA)
NP_110389 (protein)

NM_024469 (mRNA)
NP_077789 (protein)

Location

Chr 12: 26.16 - 26.17 Mb

Chr 6: 145.82 - 145.82 Mb

Pubmed search

[1]

[2]

Basic helix-loop-helix domain containing, class B, 3, also known as BHLHB3, is a human gene.^[1]

[edit] References

^ Entrez Gene: BHLHB3 basic helix-loop-helix domain containing, class B, 3.

[edit] Further reading

Grottke C, Mantwill K, Dietel M, et al. (2000). "Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs.". Int. J. Cancer 88 (4): 535-46. PMID 11058868.
Fujimoto K, Shen M, Noshiro M, et al. (2001). "Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins.". Biochem. Biophys. Res. Commun. 280 (1): 164-71. doi:10.1006/bbrc.2000.4133. PMID 11162494.
Garriga-Canut M, Roopra A, Buckley NJ (2001). "The basic helix-loop-helix protein, sharp-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism.". J. Biol. Chem. 276 (18): 14821-8. doi:10.1074/jbc.M011619200. PMID 11278948.
Miyazaki K, Kawamoto T, Tanimoto K, et al. (2003). "Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes.". J. Biol. Chem. 277 (49): 47014-21. doi:10.1074/jbc.M204938200. PMID 12354771.
Honma S, Kawamoto T, Takagi Y, et al. (2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock.". Nature 419 (6909): 841-4. doi:10.1038/nature01123. PMID 12397359.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Li Y, Xie M, Song X, et al. (2003). "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter.". J. Biol. Chem. 278 (19): 16899-907. doi:10.1074/jbc.M300596200. PMID 12624110.
Azmi S, Sun H, Ozog A, Taneja R (2003). "mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression.". J. Biol. Chem. 278 (22): 20098-109. doi:10.1074/jbc.M210427200. PMID 12657651.
Oswald F, Winkler M, Cao Y, et al. (2005). "RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.". Mol. Cell. Biol. 25 (23): 10379-90. doi:10.1128/MCB.25.23.10379-10390.2005. PMID 16287852.