Betaine-aldehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a betaine-aldehyde dehydrogenase (EC 1.2.1.8) is an enzyme that catalyzes the chemical reaction

betaine aldehyde + NAD⁺ + H₂O betaine + NADH + 2 H⁺

The 3 substrates of this enzyme are betaine aldehyde, NAD⁺, and H₂O, whereas its 3 products are betaine, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is betaine-aldehyde:NAD+ oxidoreductase. Other names in common use include betaine aldehyde oxidase, BADH, betaine aldehyde dehydrogenase, and BetB. This enzyme participates in glycine, serine and threonine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1A4S, 1BPW, 1WNB, and 1WND.

[edit] References

• IUBMB entry for 1.2.1.8
• BRENDA references for 1.2.1.8 (Recommended.)
• PubMed references for 1.2.1.8
• PubMed Central references for 1.2.1.8
• Google Scholar references for 1.2.1.8
• ROTHSCHILD HA, BARRON ES (1954). "The oxidation of betaine aldehyde by betaine aldehyde dehydrogenase". J. Biol. Chem. 209: 511–23. PMID 13192104. 
• Tsutui N, Hirasawa E (2003). "Purification and properties of betaine aldehyde dehydrogenase from Avena sativa". J. Plant. Res. 116: 133–40. doi:10.1007/s10265-003-0077-7. PMID 12736784. 
• L (2003). "Ligand-induced conformational changes of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves affecting the reactivity of the catalytic thiol". Chem. Biol. Interact. 143-144: 129–37. PMID 12604197. 
• Eklund H (1998). "Structure of betaine aldehyde dehydrogenase at 2.1 A resolution". Protein. Sci. 7: 2106–17. PMID 9792097. 
• Takabe T (2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica". J. Biol. Chem. 278: 4932–42. doi:10.1074/jbc.M210970200. PMID 12466265. 

[edit] External links

The CAS registry number for this enzyme class is 9028-90-4.

• IUBMB entry for 1.2.1.8

• KEGG entry for 1.2.1.8

• BRENDA entry for 1.2.1.8

• NiceZyme view of 1.2.1.8

• EC2PDB: PDB structures for 1.2.1.8

• PRIAM entry for 1.2.1.8

• PUMA2 entry for 1.2.1.8

• IntEnz: Integrated Enzyme entry for 1.2.1.8

• MetaCyc entry for 1.2.1.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008802: betaine-aldehyde dehydrogenase

• AMIGO entry for GO code 0008802: betaine-aldehyde dehydrogenase