Beta-pyrazolylalanine synthase

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In enzymology, a beta-pyrazolylalanine synthase (EC 2.5.1.51) is an enzyme that catalyzes the chemical reaction

O₃-acetyl-L-serine + pyrazole $\rightleftharpoons$ 3-(pyrazol-1-yl)-L-alanine + acetate

Thus, the two substrates of this enzyme are O3-acetyl-L-serine and pyrazole, whereas its two products are 3-(pyrazol-1-yl)-L-alanine and acetate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase. Other names in common use include beta-(1-pyrazolyl)alanine synthase, beta-pyrazolealanine synthase, beta-pyrazolylalanine synthase (acetylserine), O3-acetyl-L-serine acetate-lyase (adding pyrazole), BPA-synthase, pyrazolealanine synthase, pyrazolylalaninase, and 3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase.

[edit] References

IUBMB entry for 2.5.1.51
BRENDA references for 2.5.1.51 (Recommended.)
PubMed references for 2.5.1.51
PubMed Central references for 2.5.1.51
Google Scholar references for 2.5.1.51
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Murakoshi I, Ikegami F, Hinuma Y and Hanma Y (1984). "Purification and characterization of L-mimosine synthase from Leucaena leucocephala". Phytochemistry 23: 1905–1908. doi:10.1016/S0031-9422(00)84938-9.
Murakoshi I, Kuramoto H and Haginiwa J (1972). "The enzymic synthesis of beta-substituted alanines". Phytochemistry 11: 177–182. doi:10.1016/S0031-9422(00)89986-0.
Noji M, Murakoshi I, Saito K (1993). "Evidence for identity of beta-pyrazolealanine synthase with cysteine synthase in watermelon: formation of beta-pyrazole-alanine by cloned cysteine synthase in vitro and in vivo". Biochem. Biophys. Res. Commun. 197: 1111–7. doi:10.1006/bbrc.1993.2592. PMID 8280125.