Beta-lysine 5,6-aminomutase

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In enzymology, a beta-lysine 5,6-aminomutase (EC 5.4.3.3) is an enzyme that catalyzes the chemical reaction

(3S)-3,6-diaminohexanoate $\rightleftharpoons$ (3S,5S)-3,5-diaminohexanoate

Hence, this enzyme has one substrate, (3S)-3,6-diaminohexanoate, and one product, (3S,5S)-3,5-diaminohexanoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups. The systematic name of this enzyme class is (3S)-3,6-diaminohexanoate 5,6-aminomutase. Other names in common use include beta-lysine mutase, and L-beta-lysine 5,6-aminomutase. This enzyme participates in lysine degradation. It employs one cofactor, cobamide.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1XRS.

[edit] References

IUBMB entry for 5.4.3.3
BRENDA references for 5.4.3.3 (Recommended.)
PubMed references for 5.4.3.3
PubMed Central references for 5.4.3.3
Google Scholar references for 5.4.3.3
Retey J, Kunz F, Arigoni D and Stadtman TC (1978). "Zur Kenntnis der beta-Lysin-Mutase-Reaktion: mechanismus und sterischer Verlauf". Helv. Chim. Acta 61: 2989–2998. doi:10.1002/hlca.19780610824.
Stadtman TC, Renz P (1968). "Anaerobic degradation of lysine. V. Some properties of the cobamide coenzyme-dependent beta-lysine mutase of Clostridium sticklandii". Arch. Biochem. Biophys. 125: 226–39. doi:10.1016/0003-9861(68)90657-7. PMID 5649516.