Beta-ketoacyl-acyl-carrier-protein synthase II

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In enzymology, a beta-ketoacyl-acyl-carrier-protein synthase II (EC 2.3.1.179) is an enzyme that catalyzes the chemical reaction

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] \rightleftharpoons (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]

Thus, the two substrates of this enzyme are [[(Z)-hexadec-11-enoyl-[acyl-carrier-protein]]] and [[malonyl-[acyl-carrier-protein]]], whereas its 3 products are [[(Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein]]], CO2, and [[[acyl-carrier-protein]]].

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is (Z)-hexadec-11-enoyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-pr otein] C-acyltransferase (decarboxylating). Other names in common use include KASII, KAS II, FabF, 3-oxoacyl-acyl carrier protein synthase I, and beta-ketoacyl-ACP synthase II. This enzyme participates in fatty acid biosynthesis.

[edit] References

  • IUBMB entry for 2.3.1.179
  • BRENDA references for 2.3.1.179 (Recommended.)
  • PubMed references for 2.3.1.179
  • PubMed Central references for 2.3.1.179
  • Google Scholar references for 2.3.1.179
  • D'Agnolo G, Rosenfeld IS, Vagelos PR (1975). "Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli". J. Biol. Chem. 250: 5289–94. PMID 237914. 
  • Garwin JL, Klages AL, Cronan JE Jr (1980). "Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli". J. Biol. Chem. 255: 11949–56. PMID 7002930. 
  • Price AC, Rock CO, White SW (2003). "The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae". J. Bacteriol. 185: 4136–43. doi:10.1128/JB.185.14.4136-4143.2003. PMID 12837788. 
  • Garwin JL, Klages AL, Cronan JE Jr (1980). "Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli Evidence for function in the thermal regulation of fatty acid synthesis". J. Biol. Chem. 255: 3263–5. PMID 6988423. 
  • Magnuson K, Carey MR, Cronan JE Jr (1995). "The putative fabJ gene of Escherichia coli fatty acid synthesis is the fabF gene". J. Bacteriol. 177: 3593–5. PMID 7768872. 
  • Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.

[edit] External links

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