Beta-diketone hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a beta-diketone hydrolase (EC 3.7.1.7) is an enzyme that catalyzes the chemical reaction

nonane-4,6-dione + H₂O pentan-2-one + butanoate

Thus, the two substrates of this enzyme are nonane-4,6-dione and H₂O, whereas its two products are pentan-2-one and butanoate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is nonane-4,6-dione acylhydrolase. This enzyme is also called oxidized PVA hydrolase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2J5G and 2J5S.

[edit] References

• IUBMB entry for 3.7.1.7
• BRENDA references for 3.7.1.7 (Recommended.)
• PubMed references for 3.7.1.7
• PubMed Central references for 3.7.1.7
• Google Scholar references for 3.7.1.7
• Sakai K, Hamada N and Watanabe Y (1983). "Separation of secondary alcohol oxidase and oxidized poly(vinyl alcohol) hydrolase by hydrophobic and dye-ligand chromatographies". Agric. Biol. Chem. 47: 153–155. 
• Sakai K, Hamada N and Watanabe Y (1985). "A new enzyme, beta-diketone hydrolase: a component of a poly(vinyl alcohol)-degrading enzyme preparation". Agric. Biol. Chem. 49: 1901–1902. 

[edit] External links

The CAS registry number for this enzyme class is 97955-12-9.

• IUBMB entry for 3.7.1.7

• KEGG entry for 3.7.1.7

• BRENDA entry for 3.7.1.7

• NiceZyme view of 3.7.1.7

• EC2PDB: PDB structures for 3.7.1.7

• PRIAM entry for 3.7.1.7

• PUMA2 entry for 3.7.1.7

• IntEnz: Integrated Enzyme entry for 3.7.1.7

• MetaCyc entry for 3.7.1.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047699: beta-diketone hydrolase

• AMIGO entry for GO code 0047699: beta-diketone hydrolase