Beta-cyclopiazonate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a beta-cyclopiazonate dehydrogenase (EC 1.21.99.1) is an enzyme that catalyzes the chemical reaction

beta-cyclopiazonate + acceptor $\rightleftharpoons$ alpha-cyclopiazonate + reduced acceptor

Thus, the two substrates of this enzyme are beta-cyclopiazonate and acceptor, whereas its two products are alpha-cyclopiazonate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on X-H and Y-H to form an X-Y bond with other acceptors. The systematic name of this enzyme class is beta-cyclopiazonate:acceptor oxidoreductase (cyclizing). Other names in common use include beta-cyclopiazonate oxidocyclase, beta-cyclopiazonic oxidocyclase, and beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing). It employs one cofactor, FAD.

[edit] References

IUBMB entry for 1.21.99.1
BRENDA references for 1.21.99.1 (Recommended.)
PubMed references for 1.21.99.1
PubMed Central references for 1.21.99.1
Google Scholar references for 1.21.99.1
Edmondson DE, Kenney WC, Singer TP (1976). "Structural elucidation and properties of 8alpha-(N1-histidyl)riboflavin: the flavin component of thiamine dehydrogenase and beta-cyclopiazonate oxidocyclase". Biochemistry. 15: 2937–45. doi:10.1021/bi00659a001. PMID 8076.
Schabort JC, Potgeiter DJ (1971). "-cyclopiazonate oxidocyclase from Penicillium cyclopium. II. Studies on electron acceptors, inhibitors, enzyme kinetics, amino acid composition, flavin prosthetic group and other properties". Biochim. Biophys. Acta. 250: 329–45. PMID 5143340.